摘要
目的:比较4种刺激模式对大鼠晕动病的诱发效应。方法:40只雄性SD大鼠随机分成旋转方式1组、旋转方式2组、旋转方式3组、旋转方式4组和对照组。以旋转刺激前后各2d食高岭土总量的差值为评价指标。旋转方式1组和旋转方式2组分别采用交替加减速顺时针垂直旋转(18°/s^2角加速度加速,最大速度达120°/s,再以48°/s^2速度减速至0),刺激60 min和90 min;旋转方式3组采用交替加减速顺时针垂直旋转(48°/s^2角加速度加速,最大速度达120°/s,再以48°/s^2速度减速至0),刺激时间60 min;旋转方式4组采用匀速顺时针垂直旋转(120°/s),刺激时间60 min。结果:在4种刺激模式中,旋转方式1组、旋转方式2组和旋转方式3组大鼠2d高岭土摄取总量差值显著高于对照组(旋转方式2组P＜0．01,旋转方式1组和旋转方式3组P＜0．05),其中,旋转方式2组大鼠2d高岭土摄取总量差值显著高于旋转方式1组和旋转方式3组(P＜0．01)。结论:旋转方式1组、旋转方式2纽和旋转方式3组均能诱发大鼠晕动病的发生,其中旋转方式2组诱发效果较好。
Objective： To compare the effect of four stimulator to induce motion sickness in rats. Methods： 40 male SD rats were divided into four groups randomly. The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation. GroupⅠwere stimulated in a rotator with alternately variable speed for 1 h, which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s2 until the angular velocity reached 120°/s. Then the device was decelerated at an angular acceleration of 48°/s^2 until rotation stopped. GroupⅡ were treated identically except that they were rotated for 1.5 h. Group Ⅲ were stimulated with alternately variable speed for 1 h, which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s^2 until the angular velocity reached 120°/s. Then the device was decelerated at the same rate until rotation stopped. Group IV were rotated at 120°/s clockwise around a horizontal axis. Results： Among the four groups, the difference of kaolin intake before and after rotation of group Ⅰ, group Ⅱand group Ⅲ were significantly more than that of control group （ group IIP 〈 0.01, group Ⅰ and group ⅢP 〈 0.05 ）. The difference of kaolin intake before and after rotation of group Ⅱwas more than others（P 〈0.01 ）. Conclusion： The rotational stimulation of group Ⅰ, group Rand group Ⅲ can induce motion sickness in rats, and group Ⅱwere the most effective.
出处
《药学实践杂志》
CAS
2007年第2期78-79,87,共3页
Journal of Pharmaceutical Practice
基金
军队科研基金(01-L035)
