摘要
目的观察分析依那普利联合吲达帕胺治疗糖尿病高血压的疗效。方法选择符合WHO1999年糖尿病诊断标准和1999年WHO/ISH高血压诊断标准的患者64例,分为A组(治疗组)和B组(对照组)。A组服用依那普利10mg,每日1次,吲达帕胺2.5mg,每日1次;共服12周。B组服依那普利10mg,每日1次,时间同A组。治疗前、治疗中、治疗后非同日同一时间用台式血压计测坐位血压。治疗前后监测肝功能、肾功能、心电图、糖化血红蛋白(HbA1c)。结果血压A组治疗后与治疗前比较差异有极显著意义(P<0.01),A组和B组治疗后比较差异有显著意义(P<0.05);A组和B组疗效比较差异有显著意义(P<0.05)。结论依那普利与吲达帕胺联合治疗糖尿病高血压疗效可靠,不良反应小,优于单一用药,能使血压达到理想的控制目标值。
Objective To evaluate the therapeutic effects of enalapril combined with indaparnide in the treatment of diabetes accompanied with hypertension. Methods Sixty-four patients were chosen according to the diagnostic criterions of diabetes and hypertension made by WHO and WHO/ISH respectively in 1999. The patients were divided into Group A（test group） and Group B（control group） randomly. Group A was given enalapril （10 nag） and indapamide （2.5 mg ） per day for 12 weeks. Group B was treated with enalapril （10mg） per day for 12 weeks. Blood pressure was measured by mercury sphygmomanometers at the same time of different days before, during and after the treatment. Liver function, renal function, cardiogram and FIbAlc were measured both before and after the treatment. Results For the blood pressure, there was a highly significant difference before and after the treatment in Group A, P 〈 0.01, and there was a significant difference between Group A and Group B after the treatment, P 〈 0.05. For the therapeutic effects, there was a significant difference between Group A and Group B, P〈0.05. Conclusions Enalapril combined with indapamide has better effects and fewer side effects compared with the single drug in the treatment of diabetes accompanied with hypertension. The combination therapy can control the blood pressure to an expected aim value.
出处
《中国校医》
2007年第2期205-206,共2页
Chinese Journal of School Doctor
