摘要
目的探讨超敏C-反应蛋白(hs-CRP)、尿微量清蛋白(mALB)与心血管疾病的关系。方法测定了50例健康人及19例急性心肌梗死(AMI)患者,48例冠心病患者和62例原发性高血压患者hs-CRP、mALB和三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的水平。结果3组心血管疾病患者中,急性心肌梗死患者血清hs-CRP浓度9.01±4.36mg/L、尿mALB236.8±42.1mg/mmol.Cr;冠心病患者血清hs-CRP浓度4.01±1.82mg/L、尿mALB78.2±16.8mg/mmol.Cr;高血压患者血清hs-CRP浓度3.98±1.89mg/L、尿mALB102.9±22.9mg/mmol.Cr;均显著高于对照组血清hs-CRP0.99±0.79mg/L、尿mALB16.5±6.2mg/mmol.Cr(P<0.01)。hs-CRP与TG呈正相关(r=0.398,P<0.05),与HDL-C成负相关(r=-0.302,P<0.05)。mALB与三酰甘油呈正相关(r=0.357,P<0.05),与HDL-C成负相关(r=-0.338,P<0.05)。hs-CRP与mALB呈正相关(r=0.351,P<0.05)。结论hs-CRP、mALB的测定可辅助心血管疾病诊断和鉴别诊断,与TG和HDL-C联合动态观察,可预测心血管疾病的发展及判断预后。
Objective To investigate the relationship beween high sensitive C-reactive protein （hs-CRP）, mieroalbum and cardiovascular diseases. Methods Fifty healthy people （Control group）, 19 patients with acute myocardial infarction （AMI group）, 48 patients with coronary heart disease （CHD group）, and 62 patients with hypertension （Hypertension group） were involved. Serum hs-CRP, triglyeeride （TG）, total cholesterol （TC）, high-density lipoprotein cholesterol （HDL-C）, and low density lipoprotein cholesterol （LDL-C） were measured. Results The serum hs-CRP concentration in AMI group, CHD group, and Hypertension group was（9. 01± 4. 36）, （4. 01 ± 1.82） ,and（3.98± 1.89）mg/L, respectively. The urine mieroalbum concentration in AMI group, CHD group, and Hypertension group was （236.8±42.1）,（78.2±16.8） and （102.9±22.9）mg/retool · Cr. The above 2 parameters in 3 patient groups were significantly higher than those in Control group. The hs-CRP level was positively correlated with TG （r=0. 398,P〈0.05）, and negatively correlated with HDL-C （r=-0. 302,P〈0.05）. The mALB level was positively correlated with TG （r：0. 357 ,P〈0.05）, and negatively correlated with HDL-C （r= -0. 338, P〈0.05）. The hs-CRP level was positively correlated with mALB（r=0. 351,P〈0. 05）. Conclusion The measurement of hs-CRP and mALB may be helpful to diagnosis and differential diagnosis of cardiovascular diseases. Combined detection of the 2 parameters, TG and HDL-C helps predicting the outcome of cardiovascular diseases.
出处
《检验医学与临床》
CAS
2007年第4期258-260,共3页
Laboratory Medicine and Clinic
