摘要
目的:探讨新生儿脐血清VitA水平与新生儿免疫功能的关系,为婴幼儿抗感染的免疫措施提供科学依据。方法:分别采用微量荧光法、彩色单向免疫扩散法和平板法测定脐血血清VitA及血清IgG、IgA、IgM、补体C3、C4和溶菌酶的含量。结果:91例正常足月新生儿脐血清VitA平均水平为(50.03±22.87)μg/dl。有34.07%新生儿处于不同程度的VitA缺乏和亚临床缺乏状态。血清VitA分别与IgA和溶菌酶显著负相关(r1=-0.3794,P<0.05,r2=-0.4154,P<0.05);而与补体C4呈显著正相关(r=0.3403,P<0.05)。血清IgA水平与IgA、溶菌酶和补体C4间有剂量反应关系。血清补体C4有显著的男女差异(P<0.05)。结论:VitA对新生儿体液免疫功能有一定影响,特别是对非特异免疫功能有一定的促进作用。
Objective： To explore the relationship between cord blood serum vitamin A and immune function in neonates. Methods： Sermn vitamin A levels and IgA, IgG, IgM, C3, CA and lysozyme concentrations were measured by microfluorimetric method, color simple agar diffusion and agar - plate methods respectively. Results： Average level of serum vitamin A was determined as （50. 03 ± 22. 87） μg/dl in 91 full - term infants cord blood. 34. 07% of neonates had vitamin A avitaminosis and subclinical vitamin A deficiency. The significant negative correlation was found respectively between the level of vitamin A and IgA, lysozyme in cord serum. The significant positive correlation was found between the vitamin A and CA. There were dose - response relationships between vitamin A and IgA, CA, lysozyme respectively. The significant difference was found between the male and female according to CA. Conclusion： Vit A could influence humoral - mediated immunity and enhance partly nonspecifc immunity of neonate.
出处
《中国妇幼保健》
CAS
北大核心
2007年第9期1186-1189,共4页
Maternal and Child Health Care of China
基金
新疆维吾尔自治区教育厅项目(XJEDU2004S17)
关键词
维生素A
新生儿
脐血
免疫功能
Vitamin A
Neonates
Cord blood L Immune function
