摘要
目的:比较京尼平苷对不同种系、不同月龄大鼠,小鼠的肝毒性差异。方法:不同月龄的SD,Wistar大鼠,ICR小鼠灌胃给药3 d后,观察动物外观及体重的变化;称肝重量并计算其脏器指数;测定动物血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性及总胆红素(TBIL)的含量。结果:大鼠:280 mg/kg的京尼平苷可导致各组的肝重量增加,脏器指数增大,ALT,AST活性增高,TBIL含量增加,与各自空白对照组比较具有显著差异。小鼠:560 mg/kg的京尼平苷未表现出明显肝毒性,1 860 mg/kg京尼平苷导致ALT活性增高,TBIL含量增加。结论:京尼平苷对不同月龄、不同系(SD和Wistarg系)大鼠在肝毒性上未表现出显著差异;小鼠未表现出明显肝毒性。
Objective：To compare the hepatotoxicity induced by geniposide SD rat, wistar rat and ICR mouse of different age. Methods： SD rats Wistar rats and ICR mice were given geniposide intragastically for 3 days, and then changes in appearance and body weight were observed; weight of livers was measured and the organ index was calculated ; activities of serum ALT, AST and level of TBIL were determined. Results：Rats：The dosages of geniposide in 280 mg/kg could result in increasing livers weight, organ index, activities of ALT, AST and level of TBIL in serum. Mouse： The dosages of geniposide in 560 mg/kg did not induce obvious hepatotoxicity, the dosages of geniposide in 1 860 mg/kg could increase the activity of ALT and level of TBIL. Conclusious：There is no obvious difference in hepatotoxicity induced by geniposide to SD rat and Wistar rat of different age. Geniposide shows no obvious hepatotoxicity to mouse.
出处
《中国实验方剂学杂志》
CAS
2007年第4期31-33,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技基础条件平台项目(2004DEA71170)
科研院所社会公益研究专项(2004DIB2J062)
关键词
栀子
京尼平苷
肝毒性
大鼠
小鼠
Gardenia jasminoides Ellis
geniposide
hepatotoxicity
rat
mouse
