摘要
为了研究土家族民间药物四楞麻的化学成分,本文采用硅胶柱色谱、凝胶柱色谱等多种柱色谱分离,制备高效液相色谱纯化,共分离得到10个单体化合物,经各种有机波谱方法鉴定化合物结构为:6″-syringyl-sesamoside(1),去咖啡酰基类叶升麻苷(decaffeoylverbascoside,2),calcelarioside B(3),类叶升麻苷(verbascoside,4),异类叶升麻苷(isoverbascoside,5),alyssonoside(6),sesamoside(7),山栀苷甲酯(shanzhiside methyl ester,8),8-乙酰山栀苷甲酯(8-acetyl-shanzhiside methyl ester,9),7-epiphlomiol(10)。其中化合物6″-syringyl-sesamoside(1)为新环烯醚萜苷类化合物,化合物2～6为首次从该植物中分离得到的苯乙醇苷类化合物。
Phlomis umbrosa is a traditional medicinal plant, distributed in the north of China. In the west of Hubei province, its roots were used in the treatment of the rheumatic diseases in Tujia nationality. To study the chemical constituents from the rhizome of Phlomis umbrosa, chemical constituents were isolated from the plant by using repeated silica gel, toyopearl HW-40 and preparative HPLC chromatography. The structures of the compounds were elucidated on the basis of one and two dimensional NMR spectroscopic techniques and HRESI-MS. Ten compounds, 6＂-syringyl-sesamoside （1）, decaffeoylverbascoside （2） , calcelarioside B （3） , verbascoside （4） , isoverbascoside （5） , alyssonoside （6）, sesamoside （ 7 ） , shanzhiside methyl ester （ 8 ） , 8-acetyl-shanzhiside methyl ester （ 9 ）, 7- epiphlomiol （10） were isolated from P. umbrosa. Compound 1 is a new compound. Compounds 2 -6 are isolated from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2007年第4期401-404,共4页
Acta Pharmaceutica Sinica
基金
天津医科大学科学基金资助项目.
关键词
糙苏
环烯醚萜苷
苯乙醇苷
Phlomis umbrosa
iridoid glycosides
phenylethanoid glycosides
