摘要
本实验用原位杂交组化和免疫组化方法研究了黑质纹状体多巴胺系统被６－羟基多巴胺损伤后对前脑ＳＯＭ神经元的影响。结果为损伤侧纹状体中ＳＯＭ神经元基因表达水平下降，但多肽合量无明显变化。结果提示黑质纹状体多巴胺神经系统在基因转录水平调节着纹状体中ＳＯＭ神经元的功能活动。
Effect of nigrostriatal dopaminergic lesions by 6-hydroxydopamine on somatostatin neurons in the forebrain were studied by in situ hybridization histochemistry and immunocytochemistry. The results showed that the level of somatostatin gene transcription decreased significantly and the level of somatostatin peptide synthesis remained unchange in the lesioned side of striatum compared to the other side. The results imply that nigrostriatal dopaminergic system regulates the functions of somatostatin neurons in the striatum of the rat at the level of gene transcription.
出处
《神经科学》
SCIE
CAS
1996年第1期42-45,共4页
Chinese Journal of Neuroscience
关键词
生长抑素
6-羟多巴胺
原位杂交
免疫组化
somatostatin
6-hydroxydopamine
in situ hybridization
immunocytochemistry
rat
