摘要
采用行为测试和亚微结构定量分析相结合的方法，研究了Ｍｇ２＋对小鼠分辨学习和记忆巩固的影响，同时测定了海马ＣＡ３区及大脑皮层突触界面结构参数的变化。实验结果表明：慢性给予Ｍｇ２＋后，血浆及海马内Ｍｇ２＋含量有一定程度的升高，小鼠分辨学习能力显著下降，记忆巩固受到破坏，并且海马ＣＡ３区及大脑皮层的突触后致密物质（ｐｏｓｔ—ｓｙｎａｐｔｉｃｄｅｎｓｉｔｙ，ＰＳＤ）显著变薄，同时，皮层突触活性区长度亦显著缩短。以上结果提示，脑内Ｍｇ２＋水平过高造成的学习记忆过程损伤可能与其改变ＰＳＤ厚度和突触活性区长度密切相关。
The correlation between the effect of magnesium on learning and memory behavior and thestructure parameters of synaptic interface in hippocampal CA3 area and cerebral cortex were investigated in mice. The results showed that magnesium levels in plasma and hippocampi increased as a result of chronic magnesium treatment. Meanwhile, The discrimination learning capability and the retention of passive avoidance behavior. were significantly attenuated. In parallel with this, the post-synaptic density (PSD) in both of the hippocampal CA3 area and cerebral cortex became greatly thinner. Also the length of synaptic active zone in cerebral cortex was obviously shorterned. All these suggested that there might be a close relationship between the magnesium-induced impairment of learning and memory and the changes in PSD and length of synaptic active zone.
出处
《神经科学》
1996年第3期109-113,共5页
Chinese Journal of Neuroscience
关键词
海马CA3区
大脑皮层
突触界面结构
学习记忆
镁
magnesium
hippocampal CA3 area
cerebral cortex
synaptic interface structure
learning and memory
