摘要
目的:比较颞叶癫痫海马硬化者和非海马硬化者之间认知的差别,并分析颞叶癫痫患者认知下降的相关性因素。方法:收集110例颞叶癫痫患者临床资料,包括发病年龄、病程、发作情况;用修订韦氏记忆和韦氏智力量表来评价患者的记忆和智力水平;总结手术后患者的病理资料以确定患者是否伴有海马硬化。结果:伴有海马硬化颞叶癫痫患者的长期记忆和总记忆商分别为37．4±10．0,81．8±19．1;非海马硬化颞叶癫痫患者的长期记忆和总记忆商分别为42．0±8．2,88．3±13．4,伴有海马硬化颞叶癫痫患者的长期记忆和总记忆商显著低于非海马硬化颞叶癫痫患者的长期记忆和总记忆商(P值分别为0．01和0．049)。左侧起源与右侧起源的颞叶癫痫患者的语言智商分别为88．9±9．8和95．0±11．4,二者相比有显著性差异(P=0．013<0．05)。颞叶癫痫患者的总记忆商与癫痫病程呈负相关(r=-0．256,P=0．007<0．01),操作智商与癫痫发作频率呈负相关(r=-0．206,P=0．031<0．05),总智商与教育程度呈正相关(r=0．189,P=0．048<0．05)。结论:海马硬化的颞叶癫痫患者比非海马硬化的颞叶癫痫患者具有更差的长期记忆和总记忆商,左侧起源的颞叶癫痫患者比右侧起源的颞叶癫痫患者语言智商损伤更明显。颞叶癫痫患者病程越长其记忆商越差;癫痫发作越频繁其操作智商越差;教育对保护颞叶癫痫患者的智能有一定的作用。
Purpos： The goals of this work were to compare the cognitive difference of temporal lobe epilepsy （TLE） patients between with and without hippocampal sclerosis（HS） and to analyze the correlativity between cognitive decline and its effecting factors. Methods：110 TLE cases were collected and recording their clinical data including ages of onset, durations of illness and frequency of the seizures, et al. The WAIS-R and WAMS-R Scales were used to evaluate the memory and the intelligence of the collected cases. Summarizing the neuropathoiogicai findings of the patients after operations was to determine whether the individual with HS. Results： The scores of the long memory and MQ of cases with HS were respectively 37.4±10.0 and 81.8±19.1, its scores of cases without HS were respectively 42.0±8.2 and 88.3±13.4. The two scores of patients with HS were apparent lower than that of those patients without HS（P value was respectively 0.01 and 0. 049）. The Verbal IQ（VIQ） scores of the cases which seizures arisen from left temporal lobe was notable lower than that of which seizures arisen from right temporal lobe（P=0. 013〈0.05） and their scores were respectively 88.9±9.8 and 95.0±11.4. The MQ of the patients with TIrE was notable negative correlated with the durations of the illness（r= -0. 256, P=0. 007〈0. 01）, its Performance IQ（PIQ） was prominent correlated with the frequency of the seizures（r=-0. 206,P=0. 031（0.05） and their FIQ was notable positive correlated with the years of education （r= 0. 189, P = 0. 048〈0.05）. Conclusions： The TLE patients with HS had the worse long memory and MQ than those without HS and the VIQ of cases which seizures arisen from left temporal lobe was more easily suffered from illness than that of cases which seizures arisen from right temporal lobe. The more longer durations of the seizures, the more worse memory function and the more frequent seizures, the more lower PIQ. The positive correlativity between the years of education and the individual FIQ suggested education maybe protected intelligence of the TLE cases from seizures.
出处
《脑与神经疾病杂志》
2007年第2期130-133,共4页
Journal of Brain and Nervous Diseases
关键词
颞叶癫痫
记忆力
智能
认知下降
海马硬化
temporal lobe epilepsy memory intelligence cognitive decline hippocampal sclerosis
