摘要
目的:探讨血浆脑肠肽浓度与妊娠期糖尿病的相关关系。方法:利用放射免疫法测定血浆中脑肠肽及空腹胰岛素浓度,同时利用葡萄糖氧化酶法检测空腹血浆葡萄糖水平。结果:(1)妊娠期糖尿病孕妇血浆脑肠肽水平显著低于正常孕妇[(360±52 vs 740±46)pg/ml](P<0.05)。(2)妊娠期糖尿病孕妇血浆脑肠肽水平与体质指数(BMI)、空腹胰岛素及胰岛素抵抗指标成负相关(r=-0.478,-0.405,-0.517)(P<0.05)。结论:血浆脑肠肽水平可能与妊娠期糖尿病的发生发展有关。
Objective： To study the association between plasm ghrelin level and gestational diabetes mellitus （GDM）. Methods： Plasma ghrelin levels and insulin levels were measured by radioimmunoassay and fasting plasma glucose levels were measured by glucose oxidase. Results： Plasma ghrelin levels were lower in GDM （360±52） pg/ml than in normal pregnance controls （740±46）pg/ml（P〈0.05）. Significant negative linear correlations were found among fasting plasma ghrelin and body mass index （BMI）, the fasting insulin levels and insulin resistance （r = -0.478, -0.405, -0.517） （P〈0.05）. Conclusion： Plasma ghrelin levels may be associated with the pathogenesis of gestational diabetes mellitus.
出处
《天津医科大学学报》
2007年第1期46-47,72,共3页
Journal of Tianjin Medical University
关键词
脑肠肽
妊娠期糖尿病
空腹胰岛素
空腹血糖
Ghrelin
Gestational diabetes mellitus
Fasting insulin
Fasting glucose
