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尿蛋白成分与选择分数预测肾小管间质损伤程度 被引量：5

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摘要 蛋白尿、肾小管间质损伤与肾功能恶化的进展速度紧密联系。但临床上常有蛋白尿程度与小管间质损伤不平行的现象。蛋白尿的质（即尿蛋白成分）而非量可能在肾小管间质损伤过程中起重要作用，但目前尿中导致小管间质损伤的主要蛋白成分仍不确定。本研究通过检测成人原发性肾病综合征患者的尿蛋白成分，计算尿蛋白IgG选择分数（selective index，SI），分析其与小管间质损伤的关系，试图寻找可能反应肾脏病理损伤程度、预测肾功能恶化进展的非创伤性指标。
作者 李瑛 刘伏友 彭佑铭 杨丽 李军 段绍斌 刘映红
机构地区 中南大学湘雅二医院肾内科 中南大学肾脏病研究所
出处 《中华内科杂志》 CAS CSCD 北大核心 2007年第4期315-316,共2页 Chinese Journal of Internal Medicine
关键词 肾小管间质损伤 损伤程度 蛋白成分 蛋白尿 预测 成人原发性肾病综合征 肾功能恶化 非创伤性指标
分类号 R446.1 [医药卫生—诊断学]
  • 相关文献

参考文献7

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二级参考文献8

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共引文献48

同被引文献47

  • 1邵晓珊,蒋新辉,李宇红,靳蓉,仝铁.系膜增生性肾小球肾炎患儿肾组织TGF-β1的表达与临床病理意义[J].贵州医药,2011,35(4):297-300. 被引量：2
  • 2刘伏友.蛋白尿致肾小管间质纤维化的机制及防治[J].中华肾脏病杂志,2006,22(5):258-260. 被引量：39
  • 3刘伏友,李瑛,杨丽,段绍斌.成人原发性肾病综合征肾小管间质损害的危险因素分析[J].中华肾脏病杂志,2006,22(5):293-294. 被引量：14
  • 4叶琨,刘伏友,李瑛,彭佑铭,段绍斌,许向青,周乐天,李芝兰.去甲斑蝥素对蛋白负荷肾病大鼠干预的研究[J].中华肾脏病杂志,2007,23(2):82-86. 被引量：11
  • 5Takai S, Jin D, Sakaguchi M, et al. A novel chymase inhibitor, 4-[ 1 -([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3- (2- ethoxy-benzyl)-4-oxo- azetidine- 2- yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters. J Pharmacol Exp Ther, 2003,305:17-23.
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  • 9Jones SE, Kelly DJ, Cox AJ, et al. Mast cell infiltration and chemokine expression in progressive renal disease. Kidney Int, 2003,64:906-913.
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引证文献5

二级引证文献36

中华内科杂志
2007年 第4期

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