摘要
目的:比较退障凝胶与退障眼膏的体外释药特性,为研制退障凝胶提供依据。方法:以高效液相色谱法测定释放介质中大黄素、大黄酚的含量,并以此为指标,采用透析法研究退障凝胶与退障眼膏的体外释放特性。结果:退障凝胶中大黄素、大黄酚24 h的累积释放度分别为(98.3±1.1)%,(95.8±1.8)%,而眼膏剂仅为(10.62±0.7)%,(10.46±0.4)%,退障凝胶释药较眼膏剂快且完全,提高了生物利用度。结论:退障凝胶具有良好的缓释特性,作为眼部给药具有良好的开发前景。
Objective： To prepare Tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum. Method： The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method. Result： The emodin and chrysophanol in Tuizhang gel released （98.3, 1.1 ） %, （95.8, 1.8 ） % within 24 hours, respectively, while those in Tuizhang oculentum released （ 10. 62, 0.7 ）%, （ 10.46, 0.4）%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability. Conclusion： The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第8期683-687,共5页
China Journal of Chinese Materia Medica
关键词
退障凝胶
透析法
释放度
相似因子
大黄素
大黄酚
Tuizhang gel
bag filter method
dissolution
similarity factor
emodin
chrysophanol
