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糖尿病肾病尿毒症应用无糖及含糖透析液血液透析特点及其对血糖的影响 被引量:12

The influence of glucose in dialysate on blood glucose and hemodialysis in the treatment of chronic renal failure caused by diabetic nephropathy
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摘要 目的探讨糖尿病肾病尿毒症规律血液透析患者应用无糖及含糖透析液时血液透析的特点及其对血糖的影响。方法观察首都医科大学附属北京同仁医院血液透析中心28例糖尿病肾病尿毒症规律血液透析患者应用无糖和含糖透析液(葡萄糖浓度5.5mmol/L)血液透析前后的临床和生化指标,并分别进行透析开始,透析2h及透析结束时血糖测定。结果应用含糖透析液组在血压,透析间期体重增长,血红蛋白,血钾,透析充分性及营养状况,血脂等方面与应用无糖透析液组差异无显著性(P>0.05),随着透析进行,血糖下降幅度明显低于无糖透析液组,在4h末基本回复到透析开始时水平。结论糖尿病肾病尿毒症规律血液透析患者应用含糖透析液较为安全,且不影响透析效果。 Objective To study the changes of hemodialysis and blood glucose in uremic patients of diabetic nephropathy treated with dialysate with and without glucose. Methods Maintenance hemodialyis using dialysate containing 0 or 5.5mmol/L glucose was performed in 28 uremic cases due to diabetic nephropathy. Clinical manifestations and biochemistry examinations were observed before and after the dialysis. Blood glucose was determined before the dialysis, after 2 hours and the end of the dialysis. Results There were no significant differences in blood pressure, weight changes during the dialysis period, hemoglobin concentration, serum potassium, hemodialytic sufficiency, nutrition state and blood lipids between patients using dialysate containing 5.5mmol/L glucose and those using the fluid without glucose (P 〉 0.05). In the processes of dialysis, blood glucose decreased slowly and returned to their initial levels after 4 hours in the patients using 5.5mmol/L glucose in the dialysate. Conclusion Dialysis fluid containing 5.5mmol/L glucose does not alter the hemodialysis efficiency and is safe to uremic patients caused by diabetic nephropathy.
出处 《中国血液净化》 2007年第4期192-194,共3页 Chinese Journal of Blood Purification
关键词 糖尿病 尿毒症 透析 血糖 Diabetes mellitus Uremia Hemodialysis Blood glucose
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参考文献4

  • 1黎磊石.进一步重视糖尿病肾病的防治研究[J].中华医学杂志,1999,79(5):327-328. 被引量:46
  • 2黄雯主译.透析手册[M].中信出版社,2004,442.
  • 3Gutierrez A.Hemodialysis-associated protein catabolism with and without glucose in the dialysis fluid[J].Kidney Int,1999,46(3):814-822.
  • 4Heller SR.Hypoinsulinemia is not critical to glucose recovery from hypoglycemia in humans[J].Am J Physiol,2001,261(1):41-48.

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