摘要
以L-聚乳酸为模型体系,超临界CO_2为抗溶剂,采用超临界流体抗溶剂法制备聚乳酸微球。考察了压力、温度、溶液浓度、溶液流速、二氯甲烷-丙酮混合溶剂、聚合物分子量等参数对制备微球的形态、粒径及其分布的影响。结果表明,改变工艺参数,可在一定范围内调控微球粒径,所制微球平均粒径0．67～6．64μm,溶液浓度及其流速为主要影响因素;实验条件一定时,采用二氯甲烷-丙酮混合溶剂及强制分散溶液法制备得较小粒径微球。释放度实验结果表明,微球按一级释放方程释药,具缓释效果。
Microspheres of poly-L-lactide （PLLA） were prepared with a continuous supercritical anti-solvent precipitation （SAS） by using supercritical carbon dioxide as an anti-solvent. The effects of several key factors on surface morphology, and particle size and particle size distribution were investigated. These factors included pressure, temperature, concentration of the organic solution, the flow rate of the solution, mixing acetone into dichloromethane solution and different molecular weight of PLLA. The results indicated that concentration of the organic solution and the flow rate of the solution played important roles on the properties of products. Various microspheres with the mean particle size ranging from 0.64 to 6.64μm, could be prepared by adjusting the operational parameters. Fine microspheres were obtained in a solution-enhanced dispersion by supercritical fluids （SEDS） process with dichloromethane/acetone mixture as solution. The drug release of the drug-loaded microparticles was mainly in a first-order kinetics.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2007年第4期549-552,共4页
Journal of Functional Materials
基金
教育部优秀青年教师教学科研奖励基金资助课题(2002123)
关键词
超临界二氧化碳
抗溶剂法
聚乳酸
微球
supercritieal carbon dioxide
anti-solvent preeipitation
poly-L-laetide
mierospheres
