摘要
目的观察透明质酸钠(HA)复合纤维蛋白凝胶(FG)预防椎板切除术后硬膜外粘连的效果。方法新西兰兔24只,行L4、L5、L6椎板切除,72个节段分3组,分别植入HA、FG和HAFG复合凝胶。术后4、8、12周处死动物,取出腰椎,分别行大体、组织、生化及MRI研究。结果HAFG复合凝胶在局部存留时间较长,能有效地防止硬膜外粘连。单独使用HA或FG早期有一定预防粘连作用,晚期作用不明显。结论HAFG复合凝胶能减少实验动物椎板切除术后硬膜外瘢痕形成,中长期防粘连效果较单独使用两种凝胶更为可靠。
Objective To study the effect of various materials including sodium hyaluronate （HA）, fibrin glue （FG）and the combination of HA or FG（HAFG） on prevention of peridural fibrosis and adhesion（PDFA） after laminectomy. Methods Twenty-four rabbits were randomly divided into HA, FG and HAFG three groups, and each group had 8 rabbits. A 3-level lumbar laminectomy was performed on each rabbit. Materials above were applied to the laminectomy sites. PDFA were assessed by gross observation, histological examination, biochemistry examination and MRI investigation. Results the composition of HA and FG could persist more time than either HA or FG in local laminectomy sites. As a three dimensional protective material, HAFG could effectively inhibit PDFA after laminectomy, but HA or FG only had some effect in the early stage, not in the later period. Conclusion HAFG is believed to be useful in reducing epidural scar adhesion after laminectomy,and it＇s long term effect to prevent postsurgical epidural scar adhesions is satisfactory.
出处
《现代医学》
2007年第2期101-104,共4页
Modern Medical Journal
