期刊文献+

青藤碱治疗类风湿关节炎100例临床研究 被引量:16

The Clinical Study on Sinomenine for 100 Patients with Rheumatoid Arthritis
下载PDF
导出
摘要 目的观察青藤碱治疗类风湿关节炎(RA)的临床疗效。方法将169例RA患者随机分为治疗组(100例)与对照组(96例),分别采取青藤碱和雷公藤多苷片治疗,并比较治疗前后临床症状、体征的改善情况及实验室指标(ESR、RF、CRP、IgG、IgA、IgM、补体C3)的变化。结果治疗组总有效率为93.00%,对照组总有效率为67.71%;两组治疗后临床症状、体征改善,治疗组较对照组更显著;治疗组治疗后前述七项实验室指标与治疗前比较均有改善,而对照组七项指标中ESR、RF、CRP、IgA改善,且治疗组ESR、RF、CRP、IgG、IgA治疗后改善程度明显优于对照组。结论青藤碱对RA有较好的疗效,疗效优于雷公藤多苷。 Objective: To observe the effect of Sinomenine (SN) in treating rheumatoid arthritis (RA). Methods: Patients were randomly divided into two groups, 100 in the treatment group(received SN) and 96 in the control group(received tripterygium glycosides tablet). The changes of chinical symptoms and signs as well as laboratory critera, including ESR, RF, CRP, IgG, IgA, IgM, and C3 of the patients,were observed. Results: The total effective rate of the treatment group (93.00%) was obviously higher than that of the control group (67.71%). Clinical symptoms and signs were improved significantly after treatments in both groups, while the improvement of the treatment group was more obviously than that of the control group. Of the patients in the treatment group, the former, 7 items of laboratory criteria were improved significantly after the treatment, while in the controlling group, significant changes were only shown in ERS, RF, CRP and IgM, and the ERS, RF, RP, IgG and IgA of patinets in the treatment group after the treatment were all better than in the control group respectively. Conclusion: SN has better therapeutic effect for RA than tripterygium glcycosides tablet.
出处 《中国中医急症》 2007年第4期416-417,421,共3页 Journal of Emergency in Traditional Chinese Medicine
关键词 类风湿关节炎 青藤碱 Rheumatoid arthritis sinomenine
  • 相关文献

参考文献8

  • 1.中药新药临床研究指导原则(第1辑)[S].[S].中华人民共和国卫生部,1993.41-45.
  • 2陈雅研,邱翠嫦,沈莉,高从元,乔梁,王动.清风藤微量生物碱的研究[J].北京医科大学学报,1991,23(3):235-237. 被引量:26
  • 3李嗣英,王君,高萍,王瑞海.青藤碱对小鼠免疫功能的影响[J].中草药,1992,23(2):81-83. 被引量:45
  • 4Peng HM,Ding XY,Liu XS,et al.Immunologicalinhibitory effectof sinomenine[J].Acat Pharmacol Sin,1988,9(4):377 ~ 380
  • 5Liu L,Buchner E,Beitze ID,et al.Amelioration of ratexperimental arthritis by treatment with the alkaloid sinomenine[J].Int J Imm Unopharm Acol,1996,18(10):529 ~ 543
  • 6Liu Q,Zhou LL,Li S.General development ofsinomenine in chemistry,pharmacology and clinics[J].Chin Tradit Herb D Rugs,f997,28(4):247 ~ 249
  • 7倪立青 劳志英.毛青藤碱治疗类风湿性关节炎40例疗效观察[J].中级医刊,1985,(12):46-46.
  • 8高家骏,张强,吉宁,邓东,王和敏,佟大春.青藤碱单用或加用氯喹和雷公藤多苷治疗类风湿关节炎的比较[J].中国新药与临床杂志,1999,18(4):215-217. 被引量:12

二级参考文献25

  • 1梅学仁 王兆铭.抗风灵(青藤碱)的研制与临床应用.中西医结合治疗风湿类疾病学[M].天津:天津科技出版社,1989.267-70.
  • 2史甫敏 马兆兴 等.青风藤总碱治疗类风湿性关节炎60例[J].新医学,1986,17:292-4.
  • 3周惠成.抗风灵,氯喹治疗类风湿性关节炎93例疗效观察[J].中国中西医结风湿病杂志,1994,3:170-1.
  • 4刘沛霖 胡永红 等.雷公藤地上部分与地下部分类风湿性关节炎的双盲交叉对照研究[J].中国中西医结合风湿病杂志,1993,2:77-81.
  • 5侯翠英,药学学报,1985年,20卷,2期,112页
  • 6朱任宏,化学学报,1964年,30卷,3期,265页
  • 7彭慧敏,中国药理学报,1988年,9卷,4期,377页
  • 8赵德化,药学学报,1985年,20卷,11期,856页
  • 9徐卫东,中华医学杂志,1985年,65卷,9期,517页
  • 10陈丽君,中国药理通讯,1984年,1卷,3/4期,210页

共引文献265

同被引文献337

引证文献16

二级引证文献131

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部