摘要
目的观察HYT000射频热疗机联合胸腔灌注局部化疗治疗恶性胸腔积液的疗效和毒副反应及患者的生存质量。方法晚期非小细胞肺癌TNMⅢB～Ⅳ期合并胸腔积液患者共67例，KPS评分50～60分。按治疗方法随机分为2组。A组34例：射频熟疗加胸腔灌注羟基喜树碱＋白细胞介素-2治疗；B组33例：单纯胸腔灌注羟基喜树碱＋白细胞介素-2治疗。热疗2、3次／周，每次60～90min；胸腔灌注1次／周；1个疗程3周：观察近期疗效、生存质量及不良反应。结果A组在控制肺瘤及胸腔积液、改善肺不张、缓解临床症状、生存质量、KPS积分的升高及中位生存期延长方面均优于B组，差异有统计学意义（均P〈0．05）。结论射频热疗联合胸腔灌注局部化疗对晚期肺癌合并胸腔积液的治疗效果优于单纯胸腔灌注，近期疗效较理想。
Objective To observe the efficacy of treatment of malignant pleural effusion with radiofrequency hyperthermia combined with intrapleural injection and their toxic effect as well as survival quality. Methods Sixtyseven cases of non-small cell lung cancer（ NSCLC ） at TNM stage Ⅲb -Ⅳ complicated with hydrothorax were randomized into two groups according to the therapeutic method. The Karnofsky scores were 50 ～60. Group A （ n = 34 ） were treated with hyperthermia therapy for 60 ～90 minutes combined with intrapleural infusion of 10-hydroxycamptothecin （HCPT） and Interleukin-Ⅱ. Group B （ n = 33 ） were treated with only HCPT and Interleukin-Ⅱ intrapleural infusion in the same way. Hyperthermia was given twice a week and intrapleural infusion once a week,with the whole treatment lasting for 3 weeks, and then the curative effect, side effects and quality of life were evaluated. Results Group A was more effective than group B in controlling hydrothorax and the tumor,improving the pulmonary atelectasis, the clinical symptoms, the quality of life and Karnofsky＇s scales, and prolonging median survival. There was a significant difference between groups （ P 〈 0.05 ）. Conclusion It is more effective to treat the advanced NSCLC malignant pleural effusion with combination of hyperthermia therapy and intrapleural infusion. The short-term response is comparable to the results of other treatment.
出处
《中国综合临床》
北大核心
2007年第5期435-437,共3页
Clinical Medicine of China
关键词
胸腔积液
热疗
化学疗法
Pleural effusion
Hyperthermia
Chemotherapy
