期刊文献+

脂肪干细胞:细胞治疗的新选择

Adipose derived stem cells: a novel option for regenerative cell therapy
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摘要 成体干细胞在组织修复和再生中具有强大的优势并已成为一种新型的细胞治疗肢体缺血性疾病的细胞来源。本文阐述了关于脂肪组织来源的基质细胞(adipose tissue-derived stromal cells,ADSCs)在组织重建细胞治疗上的巨大潜能。ADSC最大优点在于能方便取得而且容易在体外培养。体外培养的ADSCs能够在特定条件下诱导成为成熟脂肪细胞、骨细胞、神经细胞和内皮细胞。ADSCs还能分泌一定数量的与细胞成熟有关的细胞因子。另外,近年有报道ADSC具有向心肌细胞分化的能力。这些脂肪组织来源的基质细胞有望在不久的将来取代骨髓细胞成为再生细胞治疗的重要材料。 Adult stem cells have great advantage in tissue reconstruction and regeneration. Transplantation of autologous stem cells into ischemic tissue is a novel therapeutic option for ischemic disorders. This review summarizes the potential role of adipose tissue-derived stromal cells (ADSC) on regenerative cell therapy for ischemic diseases. ADSC can be readily harvested and cultured, under specific condition,they can be induced to differentiate into adipocytes, bone, neurons,and endothelial cells. Moreover,ADSC can secrete a number of angiogenesis-related cytokines which might be suitable for regenerative cell therapy. It has also been reported that ADSC could differentiate into myocardlocytes. ADSC might be an important material for regenerative cell therapy in the near future,replaclng bone marrow cells.
出处 《第二军医大学学报》 CAS CSCD 北大核心 2007年第3期322-324,共3页 Academic Journal of Second Military Medical University
基金 全军"十一五"科技攻关项目(06G62).~~
关键词 干细胞 脂肪组织 间质干细胞移植 细胞因子类 stem cells, adipose tissue mesenchymal stern cell transplantation cytokines
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参考文献26

  • 1Tateishi-Yuyama E,Matsubara H,Murohara T,et al.Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells:a pilot study and a randomized controlled trial[J].Lancet,2002,360:427-435.
  • 2Orlic D,Kajstura J,Chimenti S,et al.Bone marrow cells regenerate infarcted myocardium[J].Nature,2001,410:701-705.
  • 3Erickson G R,Gimble J M,Franklin D M,et al.Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo[J].Biochem Biophys Res Commun,2002,290:763-769.
  • 4Safford K M,Hicok K C,Safford S D,et al.Neurogenic differentiation of murine and human adipose-derived stromal cells[J].Biochem Biophys Res Commun,2002,294:371-399.
  • 5Halvorsen Y D,Franklin D,Bond A L,et al.Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells[J].Tissue Eng,2001,7:729-741.
  • 6余方圆,卢世璧,袁玫,黄靖香,赵斌,孙明学.脂肪干细胞向软骨细胞方向诱导的初步研究[J].中国矫形外科杂志,2004,12(10):762-764. 被引量:25
  • 7Zuk P A,Zhu M,Ashjian P,et al.Human adipose tissue is a source of multipotent stem cells[J].Mol Biol Cell,2002,13:4279-4295.
  • 8Katz A J,Tholpady A,Tholpady S S,et al.Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells[J].Stem Cells,2005,23:412-423.
  • 9胡铁霞,李祖兵.新型骨组织工程种子细胞——脂肪干细胞的研究进展[J].国外医学(口腔医学分册),2005,32(1):13-15. 被引量:4
  • 10Nakagami H,Maeda K,Morishita R,et al.Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells[J].Arterioscler Thromb Vasc Biol,2005,25:2542-2547.

二级参考文献27

  • 1王大为,徐惠,郭恩覃,张明利.脂肪移植与整形外科——基础研究综述[J].中国修复重建外科杂志,1997,11(1):61-63. 被引量:6
  • 2Billings E,May JW.Historical review and present status of free fat grit autotransplantation in plastic and reconstructive surgery[ J ].Plast Reconstr Surg, 1989,83 : 368-- 381.
  • 3Fritsch EW,Heisel J, Rupp S. The failed back surgery syndrome:reaons, intraopemtive finds, and long-term results: a report of 182 opertive treatments[J]. Spine, 1996,21:626-633.
  • 4Zuk PA, Zhu M, Mizuno H, et al. Tissue Eng, 2001, 7(2) :221-226.
  • 5Zuk PA, Zlau M. Mol Biol Ceil 2002, 13 (12) :4279-4295.
  • 6Mizuno H, Hyakusoku H. J Nippon Med Seh, 2003, 70(4) : 300-306.
  • 7De Ugarte DA, Alfonso Z, Zuk PA. Immunol Lett, 2003,89 (2-3) :267-270.
  • 8Halvorsen YDC, Franklin D, Bond AL. Tissue Eng, 2001, 7 (6) :729-741.
  • 9Dragoo JL, Choi JY, Liebrman JR. J Orthop Res, 2003, 21(4) : 622-629.
  • 10Dragoo JL, Samirni B, Zhu M. J Bone Joint Surg Am, 2003, 85 (5) :740-747.

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