摘要
目的:应用经胸彩色多普勒超声心动图观察冠脉血流储备(CFR)、冠脉管径及心功能,评价其监测蒽环类药物对心脏早期毒性作用的价值。方法:选择经病理学或细胞学确诊的肺癌患者,使用蒽环类药物治疗63例,每周期治疗前、后经彩色多普勒超声实时检查CFR、左室射血分数(LVEF)、二尖瓣舒张早期流速峰值和舒张晚期流速峰值的比值(E/A)、冠状动脉主干、左前降枝内径及心电图。根据病理种类,蒽环类药物剂量相同。结果:本组治疗前CFR、冠脉内径、LVEF及E/A正常;治疗后第二周期即出现CFR值降低,随治疗周期越长,CFR值越低,第三周期出现E/A比值及冠脉内径变化,第四周期出现LVEF下降及心电图变化。结论:经胸冠脉彩色多普勒超声用于监测蒽环类药物对心脏早期毒性作用有重要临床价值。
Objective： To evaluate the early toxicity of anthracycline on heart through observing the main coronary artery, branches and flow reserve（CFR） by transthoracic coronary artery echocardiography. Methods： Sixty-three patients, who had ma- lignant tumor diagnosed by pathology or cytology （lung cancer）, were treated with anthracycline randomly. The same dose of anthracycline was used in the same kind of disease. The left ventricle ejection fraction （LVEF）, E/A, the electrocardiogram （ECG）, CFR and diameter of the main coronary artery and branches were detected in group before treated with drug and after treatment. Results： The LVEF, E/A, CFR before treated with drug were not altered in the group, the same as the diameters of the main coronary artery, the branching and the ECG, After treatment, the second cycle namely appears the CFR value to reduce, is longer along with the treatment cycle, the CFR value is lower, The third cycle appears E/A value to reduce. The fourth cycle appears the LVEF drop and the ECG change. Conclusion： It is effective to monitor the early toxicity effect of anthracycline on heart by transthoracic coronary artery echocardiography.
出处
《中国临床医学影像杂志》
CAS
北大核心
2007年第4期235-236,共2页
Journal of China Clinic Medical Imaging
基金
本课题为四川省科技厅2004年立项课题(编号:040066)
关键词
蒽环类
毒性作用
超声检查
多普勒
彩色
anthracyclines
toxic actions
ultrasonography, Doppler, color
