摘要
目的:探讨天山雪莲培养物的免疫作用。方法:小鼠灌胃给予天山雪莲培养物,剂量分别为75、150、300mg/kg,连续给药7天,观察天山雪莲培养物对小鼠碳粒廓清、对DNCB致小鼠迟发型超敏反应和对小鼠溶血素形成的影响。结果:与空白给药组相比,天山雪莲培养物(150 mg/kg)对非特异性免疫功能有一定抑制作用;300 mg/kg的天山雪莲培养物对小鼠迟发超敏反应有抑制作用,对绵羊红细胞所致小鼠特灵性抗体生成有增强作用。结论:天山雪莲培养物具有调节免疫功能作用。
Objective： The tissue culture of Saussurea involucrata has been studied for the protection of immune function activities in animal models in our research. Methods： The tissue culture of S. involucrata at the doses of 75, 150 and 300mg/kg were given to mice by intragastric administration, successive medication for 7 days, and then the effects of S. involucrata were investigated in mice by carbon clearance rate, DNCB induced delayed hypersensitivity and serum hemolysin formation. Results： The tissue culture of S. involucrata at the doses of 150mg/kg i.g., for 7 days could inhibit the non-specificity of immune function in mice. At the doses of 300mg/kg i.g., for 7 days it could have significantly inhibitory effect on delayed hypersensitivity in mice and increase the humoral immunity activity in mice. Conclusion： The tissue culture of S. involucrata had the protection effect on immune function activities.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2007年第4期238-240,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
天山雪莲
组织培养物
免疫功能
Saussurea involucrate
tissue culture
immune function
