摘要
目的探讨氨氯地平联合阿托伐他汀(阿乐)对轻中度高血压合并血脂异常患者颈动脉内膜中层厚度(IMT)及AS斑块的消退效果;方法46例轻中度高血压(新发或未系统治疗)合并血脂异常患者,用氨氯地平联合阿乐治疗12周,以高分辩率彩色多普勒超声诊断仪评价颈动脉IMT及AS斑块消退情况;另以健康自愿者30名,与观察组姓别、年龄相匹配,作对照组;结果治疗组大部分(70%)患者的血压达标,血脂异常纠正,颈动脉IMT及斑块厚度(Crouse)积分明显缩减(P<0.05)。结论氨氯地平联合阿乐治疗12周,可使轻中度高血压合并血脂异常患者的颈动脉IMT及AS斑块有明显地消退作用。
[Objective] To discuss the effect of amlodipine combined alorvastatin （ALE） on intima-media thickness （IMT） and atherosclerosis （AS） plaque of artefia carotis in patients with essential hypertension and blood-fat abnormity [Methods] 46 patients essential hypertension and blood-fat abnormity without systematic treatment were given amlodipine combined ALE for 12 weeks. We evaluated arteria Carotis IMT and As plaque by high resolution ratio color Doppler Ultrasound. 30 heathy persons were taken as control group whose sex, age were matched with treat group. [Results] The blood pressure of 70% treatment group reached. The blood-fat abnormlty improved significantly （P〈0.05） and reached the level of control group （P 〈0.05）. The area of As plaque and thickness of plaque decreased signifisanfly （P 〈0.05）, but didn＇t reach the level of control group （P 〉0.05）. [Conclusion] Patinets with essential hypertension and blood-fat abnormity were given amlodipine combined ALE for 12 weeks. The carotis artefia IMT and As Plaque decreased significantly.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第7期874-876,共3页
China Journal of Modern Medicine
