摘要
目的探讨2型糖尿病患者血小板活化与高血压和高血糖的关系。方法将128例2型糖尿病患者按有无高血压分为高血压组(n=68)和血压正常组(n=60),并选择25例正常者作为对照。应用流式细胞仪分别测定各组的活化血小板糖基化复合物(glycopropean complex of activated platelets,PAC-1)的活性,比较2组糖尿病患者活化血小板糖基化复合物活性的差异,并分析PAC-1与血压、血糖、血脂水平的相关性。结果2组糖尿病患者的活化血小板糖基化复合物活性均明显高于正常对照组,且有高血压的糖尿病组患者的活化血小板复合物的活性高于血压正常组,PAC-1活性与血糖、收缩压水平正相关。结论除高血糖外,血压升高也是导致2型糖尿病患者血小板活化水平增高的重要因素。
Objective To investigate the relationship between PAC-1 and hypertension in patients with tape-Ⅱ diabetes mellitus （DM）. Methods One hundred and twenty eight patients with DM （tape-Ⅱ ） were divided into 2 groups： hypertension group（68 cases） and normal blood pressure group（60 cases）. Flow-cytometry was used to detect the PAC-1 level, and therefore between the 2 groups was analysed. And the correlation between hypertension, hyperglycemia and PAC-1 was evaluated. Results The PAC-1 level in patients with DM cases was higher than that in control group. It was also markedly higher in patients with hypertension than that in normal blood pressure group, blood pressure and plasma glucose correlated positively with PAC-1. Condusion Hyperglycemia as sell as hypertension are main factors resulting in a high PAC-1 level.
出处
《首都医科大学学报》
CAS
2007年第2期252-254,共3页
Journal of Capital Medical University
