摘要
目的了解本地区进行变形杆菌的耐药性和产超广谱β-内酰胺酶(ESBLs)的状况。方法对连续6年检出的190株变形杆菌进行19种抗菌药物的耐药性检测,同时采用纸片扩散法进行ESBLs确证试验,统计分析。结果190株变形杆菌ESBLs的检出率为10.5%,对氨苄西林和复方新诺明的耐药率较高,为47.9%和47.4%;对妥布霉素、环丙沙星、庆大霉素、第二代头孢菌素和哌拉西林的耐药率介于13.7%～23.2%之间;而对三四代头孢、氨曲南、头霉素类、阿米卡星、加酶抑制剂复合药的耐药率均在10%以下,此外普通变形杆菌和潘尼变形杆菌的耐药率和产酶率高于奇异变形杆菌。结论变形杆菌的耐药性和产酶率可能存在种间差异,应持续对变形杆菌耐药性和产ESBLs进行监测。
Objeetive To investigate antimicrobial resistance and ESBLs - producing rates of Proteus during the period from 2001 to 2006. Methods One hundred and ninety isolates were detected by MicroScan AutoScan4 and ESBLs confirmatory test of disk diffusion. Results Twenty isolates（ 10.5% ） were found to produce ESBlas.The resistance rates to ampicillin and trimetho- prim/sulfa were up to 47.9 % and 47.4 % respectively. The resistance rates to tobramycin, ciprofloxacin gentamicin, second - generation cephalosporins and piperacillin were between 13.7% - 23,2%. And the resistance to antibiotics such as third - generation cephalusporins were all below 10%. The antimicrobial resistance and ESBLs- producing rates of Proteus vulgaris and Proteus permeri were higher than Proteus mirabilis. Conclusion There may be different among Proteus spp in antimicrobial resistance and ESBLs - producing rates.
出处
《中国热带医学》
CAS
2007年第5期784-785,共2页
China Tropical Medicine
