摘要
为观察前列腺癌患者血唾液酸(SA)与病情、疗效及血清PSA的关系,按血PSA高低将病人分为3组:A组(治疗前,17例)血PSA≥50μg/L,707%为临床C、D1、D2期,病情进展,前列腺症状或骨痛明显。B组(治疗前,6例)血PSA8~37μg/L,临床分期为C、D期,占50%。C组(治疗后,8例)血PSA<4μg/L,除临床C期1例,余均为临床B期术后,病愈或明显好转。血SA均值,A组为308mmol/L,大于B组281mmol/L及C组214mmol/L;A、C间有非常显著性差异(P<0001),尿SA结果同血SA,P<005。此外,血PSA与血SA(或尿SA)密切相关,P<001。同为阳性(或阴性)一致率血SAPSA为816%,尿SAPSA为722%。本实验所用“一步法”简便快速,血SA敏感性1000%,特异性781%,不需进口试剂或设备,有助于前列腺癌的检出与病情疗效追踪观察。
To assess the value of sialic acid (SA) as a tumor activity marker in prostatic cancer, serum SA (SSA) or urine SA (USA) were measured with simultaneous assay of prostate specific antigen (PSA) both before and under treatment with flutamide, before and after prostatectomy or orchiectomy. The mean level of SSA was higher in group A(17 advanced cases before treatment)than in group B (6 milder cases before treatment )and group C (8 cases cured or markedly improved after treatment)( P <0 001).The same was true with USA ( P <0.05).Moreover, serum PSA was closely associated with SSA or USA ( P <0.001).The simultaneous positive or negative rate of serum SA and PSA was 81.6% and that of urine SA and PSA 72.2%.The one step resorcinol method used was simple, quick and nonexpensive with a 100% sensitivity and 78.1% specificity rafe for SSA and therefore would be helpful in the evaluation of the development of the disease, efficacy of the treatment and the detection of reccurrence especially when PSA assay was not available.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1997年第2期103-106,共4页
Chinese Journal of Urology