摘要
报道了4个熊果酸酯的合成,对熊果酸、熊果酸乙酯、熊果酸辛酯进行了抗CCl4肝损伤活性检测,得出熊果酸、熊果酸乙酯、熊果酸辛酯在60mg/kg时对ALT、AST也都有显著的降低作用,其中,熊果酸与熊果酸乙酯相比较,抗肝损伤能力相差不大,而熊果酸辛酯具有显著的抗肝损伤作用,甚至优于对照组甘草酸二铵(DGL)。
This paper reports preparation of four ursolic acid derivatives, Study on protective activity of ursolic acid on CCl4 hepatic damage indicated that the ursolic acid and derivatives at the doses of 60mg/kg significantly decreased the serum AST and ALT. The ursolic acid ethylic ester showed similar activity as that of ursolic acid against hepatic damage. Compared to ursolic acid, the ursolic acid diclofop ester demonstrated more potent protection on hepatic damage, even better than DGL.
出处
《食品科技》
CAS
北大核心
2007年第3期272-273,共2页
Food Science and Technology
关键词
熊果酸衍生物
合成
抗肝损伤
ursolic acid
synthesize
protective hepatoprotective effect
