摘要
目的应用Meta-分析评价中西医结合治疗原发性肾病综合征是否有助于提高疗效;中西医结合治疗对难治性肾病综合征是否亦能提高疗效。方法以中西医结合、原发性肾病综合征为主题词,采用电子和手工检索中国生物医学文献数据库(CBMdisc)、中国期刊全文数据库(CNKI,1994～2006.12)、维普中文科技期刊数据库(1989～)、中国循证医学/Cochrane中心数据库(CEBM/CCD)、Cochrane图书馆等数据库,搜集关于中西结合治疗原发性肾病综合征的随机对照试验(RCTs);采用Cochrane协作网专用软件RevMan4.2进行统计分析。结果检索符合RCTs纳入标准的治疗原发性肾病综合征的随机对照试验16篇,共584例病人;治疗小儿原发性肾病综合征的随机对照实验4篇,共101例病人;治疗难治性肾病综合征的随机对照实验4篇,共181例病人,Meta分析显示中西医结合治疗原发性肾病综合征可以提高完全缓解率,降低复发率,对难治性肾病及小儿原发性肾病综合征亦有效。结论中西医结合治疗原发性肾病综合征可以提高疗效,减少复发;中西医结合治疗原发性肾病综合征确切疗效尚有待于设计严格的多中心、大样本随机对照实验进一步证实。
[Objective]To evaluate the therapeutic effect of the Traditional Chinese and Western Medicine combination in primary nephritic syndrome（NS） and in difficult NS. [Methods]All the randomized controlled trials（RCTs） about the therapy of NS with the Traditional Chinese and Western Medicine Combination were collected in CBM disc, CNKI（1994~2006.12）, VIP Database（1989-2006） ,CEBM/CCD and Cochrane Library by electron and craft search with the keywords of Traditional Chinese and Western Medicine Combination and primary nephritic syndrome. Then statistical analysis was carried on by RevMan 4.2 of the Corporatlve net- work . [Results] The number of RCTs consistent with our standards was 16 with a total of 584 patients. The number of RCTs about children＇s NS was 4 with a total of 101 patients, and the difficult NS was 4 with 181 patients. The analysis showed that the total relieving rate was raised and the relapse rate lowered with the treatment of Traditional Chinese and Western Medicine Combination. [Conclusion]Traditional Chinese and Western Medicine Combination is effective in the treatment of NS . But the precise effect should be further proved by the multicentre , large sample ,randomized and controlled trials.
出处
《医学临床研究》
CAS
2007年第4期549-554,共6页
Journal of Clinical Research
