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急性心肌梗死患者同型半胱氨酸和脂蛋白a的检测及临床意义 被引量：1

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摘要 目的探讨检测血清同型半胱氨酸(Hcy)和脂蛋白a[Lp(a)]在急性心肌梗死(AMI)患者治疗前后的变化情况。方法对31例AMI患者和25例健康体检者用荧光偏振免疫分析法检测Hcy,用免疫透射比浊法检测Lp(a)。结果AMI患者Hcy和Lp(a)显著高于对照组(P=0.000和P=0.008);AMI患者治疗后Hcy浓度显著下降(P=0.001),Lp(a)治疗前、后差异无统计学意义(P=0.838)。结论高Hcy和Lp(a)与AMI的发生有关,两者同时检测可以作为AMI的预防和疗效观察的辅助指标。
作者 郑利平 覃坚
机构地区 广西医科大学第三附属医院
出处 《广西医学》 CAS 2007年第3期346-347,共2页 Guangxi Medical Journal
关键词 急性心肌梗死 同型半胱氨酸 脂蛋白A 荧光偏振免疫分析法 免疫透射比浊法
分类号 R543.31 [医药卫生—心血管疾病]
  • 相关文献

参考文献6

  • 1王真,郭静萱,王天成,赵一鸣,毛节明,陈小平.同型半胱氨酸与冠状动脉病变关系的分析[J].中华内科杂志,2000,39(7):443-445. 被引量：36
  • 2许翔,陆元善.冠状动脉病变患者血清同型半胱氨酸和非高密度脂蛋白胆固醇检测[J].检验医学,2006,21(4):324-327. 被引量：15
  • 3Huitberg B, Anderson A, saksson A. Metabolism of homocysteine, its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line (human histiocytic cell line U2 937) [J]. Biochim Biophys Acta, 1995,1269( 1 ) :6 - 12.
  • 4Kokae k, kato H, miyata T. Homocysteine respondent genes in Vascular endothelial cells identified by differentied display analysis GRP78/Bip and novel genes [ J ], J Bial chem, 1996,271 ( 47 ) : 29659 - 29665.
  • 5Mujumdar VS, Hayden MR, Tyagi SC. Homocystine induces calcium second messager in vascular smooth muscle cells[J]. J cell physiol,2000,183(1) :28 -36.
  • 6Valentine RJ, Kaplan HS, Green K, et al, lipopretein (a), homocysteine,and hypercoagulable states in young men with premature peripheral atheresclerosis : a prospective controlled analysis [ J ]. J Vasc Surg,1966,23 ( 1 ) :56 -61.

二级参考文献9

  • 1陈灏珠，实用内科学（第10版），1997年，1225页
  • 2Hultberg B,Andersson A,Isaksson A.Metabolism of homocysteine,its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line(human histiocytic cell line U2937)[J].Biochim Biophys Acta,1995,1269:6212.
  • 3Mujumdar VS,Hayden MR,Tyagi SC.Homocyst-(e) ine induces calcium second messager in vascular smooth muscle cells[J].J Cell Physiol,2000,183:28-36.
  • 4Accinni R,Campolo L,Bartesaghi S,et al.High-performance liquid chromatographic determination of total plasma homocysteine with or without internal standards[J].J Chromatog A,1998,828:397-400.
  • 5Valentine RJ,Kaplan HS,Green K,et al.Lipoprotein (a) 、 homocysteine,and hypercoagulable states in young men with premature peripheral atherosclerosis:a prospective controlled analysis[J].J Vasc Surg,1996,23:53-61.
  • 6Grundy SM.Low-density lipoprotein,non-high-density lipoprotein,and apolipoprotein B as targets of lipidlowering therapy[J].Circulation,2002,106:2526-2529.
  • 7Bittner V,Hardison R,Kelsey SF,et al.Non-high-density lipoprotein cholesterol levels predict five-year outcome in the bypass angioplasty revascularization investigation (BARI)[J].Circulation,2002,106:2537-2542.
  • 8Wood D.Established and emerging cardiovascular risk factors[J].Am Heart J,2001,141:S49-S57.
  • 9Chambers JC,Ueland PM,Obeid OA,et al.Improved vascular endothelial function after oral B vitamins:an effect mediated through reduced concentrations of free plasma homocysteine[J].Circulation,2000,102:2479-2483.

共引文献46

同被引文献6

  • 1冯青俐,党瑜华.肝细胞生长因子与冠状动脉狭窄程度的相关性研究[J].中国循环杂志,2005,20(2):102-104. 被引量：4
  • 2Sato T, Yoshinouchi T, Sugimoto T, et al. Prognostic value of serum hepatocyte growth factor in patients with acute coronary syndromes [J]. Jpn Circ J,1999,63(8) :583 -588.
  • 3Heesehen C, Dimmeler S, Hamm CW, et al. Prognostic significance of angiogenic growth factor serum levels in patients with acute coronary syndromes [ J ]. Circulation,2003,107 (4) :524 - 530.
  • 4Ueda H, Imazu M, Hayashi Y, et al. analysis of hepatocyte growth factor in human coronary atherectomy specimens: comparison with transforming growth factor beta isoforms [ J ]. Virchows Arch,1997,430(5) :407 -415.
  • 5Nakamura Y, Morishita R, Higaki J, et al. Expression of local hepatocyte growth factor system in vascular tissues [ J ]. Biochem Biophys Res Commun,1995,215(2) :483 -488.
  • 6郑宝石,胡建国,何巍,陈铭伍,温仁祝,郭建极,冯旭,冼磊.肝细胞生长因子对大鼠心脏移植细胞凋亡的影响[J].广西医学,2008,30(1):4-5. 被引量：1

引证文献1

广西医学
2007年 第3期

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