摘要
目的观察咪唑安定肌注作为椎管内麻醉前用药的镇静作用和对术中记忆遗忘的程度。方法选择ASAⅠ～Ⅱ级择期在腰硬联合阻滞下行妇科手术的病人200例,随机分为两组,每组100例,A组为咪唑安定组,对照组B组为苯巴比妥钠组。A组入室后麻醉前5分钟肌注咪唑安定0.1mg/kg,B组入室前肌注苯巴比妥钠0.1g,采用Ramsay镇静评分,记录BP、HR、RR、SPO2等的变化,术后24h随访病人,评价患者对麻醉操作及手术操作的遗忘程度。结果两组患者在用药前后BP、HR、RR、SPO2无显著性变化(p>0.05)。A组对麻醉和手术操作的完全遗忘率为88%,不全遗忘率为12%,而B组的完全遗忘率为0,不全遗忘率为24%,无遗忘率为76%。两组比较差异显著。结论麻醉前肌注咪唑安定,使患者消除焦虑、恐惧心理,对麻醉和手术操作有很好的镇静和记忆遗忘作用。
Objective To explore the effect of Midazolam intramuscular injection as a medicine used before combined spinal -epidural anesthesia on calming down the patients and their forgotten degree of operating memory. Methods 200 patients scheduled for gynaecological surgery under epidural or CSEA （Classified as ASA Ⅰ - Ⅱ ） were included in the study. Patients were randomly assigned into two groups with 100 cases each. Group A used Midazolam while Group B used Premedication of Sodium phenobarbiturate. After entering the operating room, Group A used Midazolam （0. 1mg/kg） as intramuscular injection 5 minutes before anesthesia. On the other hand, Group B used Premedication （0. 1 g） as intramuscular injection before entering the operating room. Then, used Ramsay to score, recording the changes of BP, HR, RR, SPO2 and so on. 24 hours after the operation, randomly visited the patients to evaluate the patients＇ forgotten degree of anesthesia and surgical operation. Results Referring to all patients, there were not any significant differences in BP, HR, RR, SPO2 （p 〉0. 05）. All these were within normal ranges. Referring to Group A , the complete forgotten rate of being anaesthetized and surgical operation was 88% while the uncomplete forgotten rate was 12%. In contrast, in Group B, the complete forgotten rate was 0, the uncomplete forgotten rate was 24% while unforgotten rate was 76%. There was a significant difference between them. Conclusion Injecting Midazolam （0. 1 mg/kg） as intramuscular injection 5 minutes before anesthesia can reduce the patients＇ worries and horrors. It not only helps to keep patients quiet but also cooperate with being anaesthetized andoperating body position. It has a good calm and memory -forgotten effect on anesthesia and operation.
出处
《现代医院》
2007年第4期48-49,共2页
Modern Hospitals
关键词
椎管内麻醉
咪唑安定
苯巴比妥钠
镇静
记忆遗忘
Intravertebral anesthesia, Midazolam, Sodium phenobarbiturate, Calm down, Memory - forgotten
