摘要
目的建立用紫外分光光度法测定尼美舒利栓中尼美舒利的含量。方法用不同的有机溶剂萃取尼美舒利栓中的基质,用紫外分光光度法测定尼美舒利的含量。结果用正己烷作为萃取剂,回收率高(94.4%)。用紫外分光光度法测定尼美舒利栓的含量,标准曲线线性好(r=0.9999)、精密度高(日内RSD=0.47%)、回收率高(98.3%)。结论用紫外分光光度法测定尼美舒利栓剂的含量,方法简便、快速、结果准确,可作为尼美舒利含量测定的方法。
OBJECTIVE To establish a method for determination of Nimesulide in suppositories. METHODS Screening different organic solvent to extract 36 type semi-sythetic fatty acid ester in suppositories and determinating Nimesulide by UV. RESULTS N-Hexano was used as the solution of extraction. A good linearity was within the concentration range of 3 - 15μg/mL with a Borrelation coefficient of 0. 9999. The average recovery was 98.3%. The RSD for reproducibility was 0.47%. CONCLUSION The method is simple, accurate and reliable.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2007年第2期151-153,共3页
Chinese Journal of Modern Applied Pharmacy
