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p38蛋白激酶抑制剂对大鼠膝骨关节炎的软骨保护作用 被引量:11

Chondroprotective effect of p38 mitogen activated protein kinase inhibitor on experimental rats osteoarthritis
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摘要 目的观察p38丝裂原活化蛋白激酶(p38 MAPK)抑制剂SB203580对大鼠膝骨关节炎(OA)的软骨保护作用。方法将40只大鼠随机均分为A、B、C、D组,均行单侧膝关节前交叉韧带切断。A、B组术后分别于关节腔注射0.1ml浓度为100、10μm/L的SB203580,每周1次,连续6周;C组注射等量生理盐水;D组不做任何处理。术后6周处死动物,比较各组软骨的大体变化、OA评分、软骨表面分级及Mankin炎性分级。结果A、B组软骨大体评分、软骨表面分级及Mankin炎性分级均轻于C、D组。结论关节腔注射p38 MAPK抑制剂能延缓软骨退变程度,具有软骨保护作用。 [Objective] TO observe the protective effect of p38 mitogen activated protein kinase inhibitor SB203580 on cartilage of experimental rats osteoarthritis (OA). [Methods] 40 SD rats underwent unilateral anterior cruciate ligament transection (ACLT).and were randomly divided into A,B,C,D groups. Rats of group A and B received 0. 1 ml intra-articular injection of SB203580 at 100, 10 μm/L after surgery immediately for 6 weeks, once a week. Intra-articular of those in group C received 0.1 ml 0.9% sodium chloride ,group D were not injected as control. On the 6th week after surgery,the rats were sacrificed. The cartilage changes,OA grade,cartilage surface class and Mankin inflammation class were compared. [Results] The cartilage changes,cartilage surface class and Mankin inflammation class in group C and D were more severe than those in experimental group A,B. [Conclusion] It is suggested that p38MAPK inhibitor SB203580 might reduce the severity of cartilage degeneration and have the chondroprotective effect.
出处 《山东医药》 CAS 北大核心 2007年第10期21-22,共2页 Shandong Medical Journal
基金 国家自然科学基金资助项目(30571874)
关键词 p38丝裂原活化蛋白激酶抑制剂 动物模型 骨关节炎 软骨 p38 MAP kinase inhibitor animal model osteoarthritis cartilage
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参考文献5

  • 1Pelletier JP,Martel-Pelletier J,Abramson SB,et al.Osteoart-hritis,an inflammatory disease:potential implication for the selection of new therapeutic targets[J].Arthritis Rheum,2001,44(26):1237-1247.
  • 2Bluteau G,Gouttenoire J,Conrozier T,et al.Differential gene expression analysis in a rabbit model of osteoarthritis induced by anterior cruciate ligament (ACL) section[J].Biorhelogy,2002,39(14):247.
  • 3陈百成,张洪斌,张汉杰,郑淑梅.生长因子对软骨细胞的作用[J].中华骨科杂志,1999,19(12):746-748. 被引量:25
  • 4Koh O,Jiahuai H.The p38 signal transduction pathway activation and function[J].Cellular Signalling,2000,12(18):1-13.
  • 5Lisnock J,Tebben A,Frantz B,et al.Molecular basis for p38 protein kinase inhibitor specificity[J].Biochemistry,1998,37(47):16573-16581.

二级参考文献1

  • 1Wang J S,Acta Orthop Scand,1993年,64期,557页

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