摘要
采用气相色谱-质谱（GC-MS）分析技术，建立了同时检测人血液样品中10种常见精神类药物的新方法。通过对提取溶剂、酸度等预处理条件及GC-MS分析条件的优化，可以同时检测尼可刹米、利多卡因、苯巴比妥、安乃近、阿托品、异丙嗪、卡马西平、地西泮、氯丙嗪及氯氮平这10种常见的精神类药物。在选定的条件下，尼可刹米等7种药物在0．10～25．0mg／L范围内线性关系良好；异丙嗪等3种药物在0．50～25．0mg／L范围内线性关系良好，方法回收率在77％-97％之间；RSD小于7％；检出限为5～40μ／kg。
A new method for the simultaneous determination of 10 mental drugs with amide structure in human blood by gas chromatography mass spectrometry （GC-MS） is described. In this method, the conditions for extracting solvent, pH of the reaction environment and GC-MS were investigated and optimized. The linear range of the determination nikethamide, lidocaine, phenobarbital, noramidopyrine, atropine, carbamazepine, chlorpromazine was 0.1 - 25 mg/L, and promethazine, diazepam, clozapine was 0.5 - 25 mg/L. The average recoveries of nikethamide, lidocaine, phenobarbital, noramidopyrine, atropine, carbamazepine, chlorpromazinc, promethazine, diazepam, clozapine were 77% -97%. The relative standard deviations were less than 7.0%. The determination limits were 5 - 40 μg/kg. The advantage of this method is simple, rapid and sensitive. It has been proved to be reliable, accurate and suitable for the medicine monitoring.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2007年第4期500-504,共5页
Chinese Journal of Analytical Chemistry
基金
广东省科技计划资助项目(No.2004B32401002)
关键词
气相色谱-质谱
血液
精神类药物
酰胺结构
电荷密度
PM3半经验计算
Gas chromatography-mass spectrometry, human blood, mental drugs, amide structure electron density, parametric method number 3 semiempirical calculations
