摘要
目的及时掌握菌痢发病情况及主要特征,了解志贺氏菌血清型别和耐药谱的变化,指导临床用药。方法志贺氏菌监测、分离、鉴定依照《全国细菌性痢疾监测方案》,药敏试验采用K-B扩散法。结果185例腹泻病患者中检出42株痢疾杆菌,占腹泻发病率22.7%。福氏菌39株,占92.9%,其中F4c菌24株(57.1%),F2a菌5株(11.9%),F1a菌8株(19.0%),Fx变种2株(4.7%);宋内氏菌3株(7.1%);10种抗生素体外药敏试验显示福氏志贺菌与宋内志贺菌耐药谱存在差异,福氏菌对萘定酸、复方新诺明和利福平的耐药率,分别为100%、82.05%和79.49%,而宋内菌均为100%耐药。结论F4c痢疾杆菌为郑州市菌株流行的优势菌株,临床治疗应在药敏试验指导下进行。
Objective To investigate the incidence, clinical symptom, serotype distribution and variance of antibiotics resistance of ShigeUosis for the guidance of clinical medication. Methods According to the ＂Project for Surveillance of ShigeUosis in China＂, the detection, isolation and identification for Shigena spp were performed. K-B diffusion method was used to test drug susceptibility. Results 42 strains of ShigeUa were isolated from 185 diarrhea cases （22. 7% ） , among them, 39 strains were S. flexneri, 92% （39/42） , and 3 strains were S. sonnei, 7.1% （3/42）. Among the 39 strains ofS. flexneri, 24 strains were F4c （57.1%）, 8 strains were Fla （19.0%）, 5 strains were F2a （11.9%） and 2 strains were Fx variety （4.7%）. F4c was the major prevalence serotype. Ten kinds of antibiotics susceptibility test showed that both S. flexneri and S. sonnei were resistant to nalidixic acid, SMZ-TMP and SMZ-TMP, the resistance rates of S. flexneri strains were 100%, 82.05% and 79.49% respectively, while S. sonnei strains were 100% drug resistant. Conclusion
出处
《公共卫生与预防医学》
2007年第2期18-20,共3页
Journal of Public Health and Preventive Medicine
关键词
志贺氏菌
药敏试验
优势菌株
耐药性
Shigella spp
Susceptibility test
Major prevalence serotype
Antibiotics resistance
