摘要
内毒素血症是现代急诊医学面临的一个常见而复杂的难题，应在其发病早期给予干预以阻止病情进一步发展为内毒索休克和多器官功能障碍综合征。根据内毒索血症发生的病理机制，内毒索血症的早期治疗措施包括：（1）抑制内毒素合成和释放；（2）促进内毒素的灭活和排出；（3）减少肠道内毒素的产生和吸收；（4）拮抗及中和内毒素；（5）阻断内毒素与受体结合；（6）阻断内毒素细胞内信号转导通路；（7）抑制炎症介质的作用。探索更加合理、有效干预治疗方法的研究仍在继续。
Endotoxemia is a very common and complicated problem faced by modern critical medicine. ETM should be effectively treated as early as possible to stop its developing into endoxin shock and multiple organ dysfunction syndrome. According to the pathogenic mechanisms of ETM, the early stage treatments include： （1）Inhibition the synthesis and releasing of endotoxin. （2） Acceleration the inactivation and discharge of endotoxin. （3）Reduction the production and absorption of endotoxin in digestive tract. （4）Antagonizion and neutralization the endotoxin. （5）Blockade the combination between endotoxin and its receptors. （6）Blockade the passageway of signal conductions inner cells. （7）Inhibition the effection of inflammation mediators. Searching for more reasonable treatment measures and more powerful interference ways is still going on.
出处
《世界急危重病医学杂志》
2007年第3期1884-1888,共5页
internationl journal of emergency and critical care medicine
