摘要
目的对比单纯免疫治疗与联合肝动脉化疗栓塞术治疗(TACE)晚期肝癌的临床效果。方法96例中晚期肝癌患者分为两组,A组(n=48):单纯免疫治疗;B组(n=48):免疫治疗+TACE组,比较两组病人的疗效及毒副作用。结果总有效率A组为6.3%,B组为39.6%;一年存活率A组为6.3%,B组为45.8%;A组主要副作用为发热,B组主要毒副作用为白细胞下降、发热、肝功能降低等。结论免疫治疗+TACE为部分中晚期肝癌的标准方案,疗效确实,具有一定的副作用,但患者能够耐受,而单纯免疫治疗则无明显毒副作用,患者生活质量较高,更易于接受。
Objective To compare the therapeutic effects of immunotherapy or combining with transcatheter arterial chemoembolization （TACE） on 96 patients with advanced hepatocellular carcinoma （HCC）. Methods Among the 96 patients, 48（Group A）were treated with immunotherapy alone and the other 48 patients （Group B） treated with TACE and immunotherapy. The survival time,therapeutic effects and side effects were analysed and compared between the two groups. Results The total effective rate was 6.3% in Group A and 39.6% in Group B. The median survival time was 6.6 months and 11.3 months in Groups A and B. The one year survive rate was 6.3% for Group A and 45.8% for Group B. The main side effects were fever for Group A ,but hypoleucocytosis, fever, and depressed liver function for Group B. Conclusion The therapeutic effects of immunotherapy combined with TACE are better than immunotherapy alone, and the side effects are more apparent but still tolerable.
出处
《西部医学》
2007年第3期390-391,394,共3页
Medical Journal of West China
关键词
肝癌
肝细胞
免疫治疗
肝动脉化疗栓塞术
Hepatocellular carcinoma
Transcatheter arterial chemoembolization
Immunotherapy
