摘要
目的探讨阻塞性睡眠呼吸暂停/低通气综合征患者血浆一氧化氮、内皮素1和可溶性P选择素水平的变化及持续气道正压通气治疗对其的影响。方法持续气道正压通气治疗前后分别采用硝酸盐还原酶法、放射免疫均相竞争分析法和酶联免疫法测定阻塞性睡眠呼吸暂停—低通气综合征患者血一氧化氮、内皮素1和可溶性P-选择素水平。结果阻塞性睡眠呼吸暂停/低通气综合征患者血一氧化氮水平(63.41±27.68μmol/L)明显低于健康对照者(83.26±47.74μmol/L),内皮素1水平(71.56±23.33μg/L)和可溶性P选择素水平(131.13±77.93mg/L)明显高于健康对照者(58.49±15.02μg/L和32.90±55.73mg/L);但阻塞性睡眠呼吸暂停/低通气综合征患者血一氧化氮水平明显高于伴有心脑血管疾病患者(59.59±34.19μmol/L),内皮素1水平和可溶性P选择素水平明显低于伴有心脑血管疾病患者(89.01±44.87μg/L和160.83±125.45mg/L)。持续气道正压通气治疗可明显提高一氧化氮水平(60.46±23.53μmol/L比75.11±23.91μmol/L)、降低内皮素1(73.60±20.78μg/L比61.84±18.79mg/L)和可溶性P选择素(137.34±90.35μg/L比89.56±34.60mg/L)水平(P<0.05)。结论阻塞性睡眠呼吸暂停/低通气综合征患者无论是否合并心脑血管疾病,血浆一氧化氮、内皮素1和可溶性P选择素均存在明显异常;而持续气道正压通气治疗可有效纠正其异常。
Aim To observe the levels of nitric oxide, endothelin- 1 and soluble P-selectin in patients with obstructive sleep apnea/hyponea syndrome and determine whether continuous positive airway pressure treatment has effect on them. Methods Blood concentration of nitric oxide, endothelin-1 and soluble P-selectin, the markers of vascular endothelial cell function, were determined by nitrate reduetase, radioimmunoassay, and enzyme-linked immunoassay, respectively. Results Compared with healthy controls （83.26± 47.74μmol/L, 58.49±15.02 ng/L and 32.90±55.73 mg/L; respectively）, the levels of nitric oxide, endothelin-1 and soluble P-selectin both in patients without cardiovascular disease （63.41 ± 27.68μmol/L, 71.56±23.33 ng/L and 131.13±77.93 mg/L; P〈 0.05） and in those with cardiovascular disease （59.59± 34.19μmol/L, 89.01 ± 44.87 ng/L and 160.83 ± 125.45 mg/L; P 〈 0.05） were significantly changed. However, after continuous positive airway pressure treatment, the blood concentration of nitric oxide （ 60.46 ± 23.53 μmol/L vs 75.11 ± 23.91 /nnol/L; P = 0. 025 ）, endothelin- 1 （ 73.60 ± 20.78 ng/L vs 61.84 ± 18.79 ng/L; P = 0.031 ） and soluble P-selectin （ 137.34 ± 90.35 mg/L vs 89.56 ± 34.60 mg/L; P = 0. 013 ） were significantly improved. Conclusions Obstructive sleep apnea/ hyponea syndrome patients, no matter whether complicated by cardiovascular diseases or not, have significant vascular endothelial cell dysfunction, which can be improved through the continuous positive airway pressure treatment.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第1期54-56,共3页
Chinese Journal of Arteriosclerosis
基金
浙江省医药卫生科学研究基金(2003B018)
