期刊文献+

透皮促渗剂对吲哚美辛和沙丁胺醇透皮作用的影响 被引量:7

Effect of transdermal penetration enhancers on permeation ability of indomethacin and salbutamol
下载PDF
导出
摘要 目的:研究不同透皮促渗剂对吲哚美辛和沙丁胺醇体外经皮渗透的促进作用。方法:用Valia-Chien水平扩散池,选择氮酮、丙二醇、N-甲基-吡咯烷酮、油酸、薄荷油、氮酮与丙二醇合用作为促进剂,离体SD大鼠腹部皮肤用促渗剂预处理,紫外分光光度法测定接收液中的药物含量。结果:与空白对照组比较,除了丙二醇对吲哚美辛和沙丁胺醇体外经皮渗透有抑制作用外,其余促进剂均显著提高二者的渗透速率(P<0.01),尤其以氮酮与丙二醇合用的促渗效果最好,吲哚美辛、沙丁胺醇的渗透速率分别达125.91、155.94μg·cm-2·h-1。结论:氮酮与丙二醇合用、氮酮、N-甲基-吡咯烷酮、油酸、薄荷油可作为促渗剂用于复方吲哚美辛的透皮制剂。 Objective:To study the effect of different transdermal penetration enhancers on the skin permeation ability of indomethacin and salbutamol in vitro. Methods: Valia-Chien diffusion cell was adopted as the apparatus for in vitro skin permeation test. Excised SD-rat abdomen skin was pretreated with penetration enhancers including Azone, Propylene glycol, N- methylpyrrolidone, oleic acid, peppermint oil, and a combination of Azone and Propylene glycol. A UV method was established to determine the contents of indomethacin and salbutamol in receiver diffusion cells. Results: Compared with blank control group, all the enhancers showed significant enhancement effect on the permeability of indomethacin and salbutamol except for propylene glycol (P 〈 0. 01). Azone combined with propylene glycol showed the greatest ability to enhance the flux of indomethacin(125.91 μg·cm^-2·h^-1) and salbutamol(155.94μg·cm^-2·h^-1). Conclusion: Azone combined with Propylene glycol, Azone,N-methylpyrrolidone, Oleic acid, and Peppermint oil can be used as penetration enhancers in the transdermal preparation of compound indomethacin.
出处 《第二军医大学学报》 CAS CSCD 北大核心 2007年第4期421-424,共4页 Academic Journal of Second Military Medical University
关键词 吲哚美辛 沙丁胺醇 透皮促渗剂 皮肤吸收 indomethacin albuterol penetration enhancer skin absorption
  • 相关文献

参考文献5

  • 1毕殿洲.药剂学[M].北京:人民卫生出版社,1999.131.
  • 2Mitragotri S.Synergistic effect of enhancers for transdermal drug delivery[J].Pharm Res,2000,17:1354-1359.
  • 3Finnin B C,Morgan T M.Transdermal penetration enhancers:applications,limitations,and potential[J].J Pharm Sci,1999,88:955-959.
  • 4Karande P,Jain A,Mitragotri S.Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery[J].J Contr Rel,2006,115:85-93.
  • 5Williams A C,Barry B W.Penetration enhancers[J].Adv Drug Deliv Rev,2004,56:603-618.

共引文献65

同被引文献131

引证文献7

二级引证文献79

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部