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肝移植术后移植物抗宿主病一例 被引量：1

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摘要 移植物抗宿主病（graft versus host disease GVHD）多见于异基因造血干细胞移植术后，是导致移植失败和患者死亡的主要原因之一。肝移植术后的GVHD十分罕见，文献报道发生率为1％左右。我院于2005年10月至2006年1月成功诊治1例肝移植术后GVHD，现对该患者的临床资料进行总结，分析肝移植术后GVHD的早期诊断和治疗。
作者 高鹏骥 王东 朱继业 栗光明 朱凤雪 黄磊 高杰 冷希圣
机构地区 北京大学人民医院肝胆外科北京大学器官移植中心
出处 《中华普通外科杂志》 CSCD 北大核心 2007年第4期308-309,共2页 Chinese Journal of General Surgery
关键词 移植物抗宿主病 肝移植术后 异基因造血干细胞 GVHD 临床资料 早期诊断 发生率
分类号 R686 [医药卫生—骨科学]
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参考文献10

  • 1Taylor AL, Gibbs P, Bradley JA. Acute graft versus host disease following liver transplantation: the enemy within. Am J Transplant ,2004,4:466-474.
  • 2Smith DM, Agura E, Netto G, et al. Liver transplant-associated graft-versus-host disease. Transplantation ,2003,75 : 118-126.
  • 3梁廷波,汤晓锋,郑树森,卢安卫,王伟林,沈岩,张珉,孟雪芹.肝脏移植术后移植物抗宿主病三例报告[J].中华医学杂志,2004,84(10):826-829. 被引量：23
  • 4Key T, Taylor CJ, Bradley JA, et al. Recipients who receive a human leukocyte antigen-B compatible cadaveric liver allograft are at high risk of developing acute graft-versus-host disease.Transplantation, 2004,78 : 1809-1811.
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  • 8Kleeberger W, Rothamel T, Glockner S, et al. Laser-assisted mierodisseetion and short tandem repeat PCR for the investigation of graft chimerism after solid organ transplantation. Pathobiology,2000,68 : 196-201.
  • 9Lehner F, Becker T, Sybrecht L, et al. Successful outcome of acute graft versus host disease in a liver allograft recipient by withdrawal of immunosuppression. Transplantation, 2002, 73 :307 -310.
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二级参考文献1

共引文献22

同被引文献9

  • 1周彦明,杨甲梅.肝移植术后腹泻的相关病因及处理[J].中国普外基础与临床杂志,2007,14(2):155-158. 被引量：3
  • 2Smith DM, Agura E, Netto G, et al. Liver transplant-associated graft-versus-host disease[J]. Transplantation, 2003; 75 (1):118
  • 3Taylor AL, Gibbs P, Bradley JA. Acute graft versus host disease following liver transplantation: the enemy within [J]. Am J Transplant, 2004; 4(4):466
  • 4Bettens F, Tiercy JM, Campanile N, et al. Microchimerism after liver transplantation: absence of rejection without abroga tion of anti-donor cytotoxic T-lymphocyte-mediated alloreactivity[J].Liver Transpl, 2005,11(3):290
  • 5Schappi MG, Belli DC, Rimensberger PC, et al. Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia [J]. Liver Transpl, 2006; 12(11): 1693
  • 6Pollack MS, Speeg KV, Callander NS, etal. Severe, late onset graft-versus-host disease in a liver transplant recipient documented by chimerism analysis [J]. Hum Immunol, 2005 ; 66 (1) : 28
  • 7Meves A, el-Azhary RA, Talwalkar JA, etal. Acute graft versus-host disease after liver transplantation diagnosed by fluorescent in situ hybridization testing of skin biopsy specimens [J].J Am Acad Dermatol, 2006,55(4):642
  • 8Wang B, Lu Y, Yu L, etal. Diagnosis and treatment for graftversus-host disease after liver transplantation:two case reports[J].Transplant Proc, 2007,39(5):1696
  • 9Chinnakotla S, Smith DM, Domiati-Saad R, etal. Acute graft versus host disease after liver transplantation: role of with drawal of immunosuppression in therapeutic management[J]. Liver Transpl, 2007, 13(1):157

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中华普通外科杂志
2007年 第4期

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