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双膦酸盐抗骨肿瘤作用的研究进展 被引量：1

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摘要 双膦酸盐（bisphosphonates，BPs）是近20年发展起来的抗代谢性骨病的一类新药，主要用于治疗骨质疏松症，变形性骨炎和恶性肿瘤引起的高钙血症和骨痛症等。除了强大的抗骨吸收功能外，BPs抗肿瘤作用受到越来越多的重视。
作者 何贤峰 杨述华 胡勇
机构地区 华中科技大学同济医学院协和医院骨科
出处 《中国骨肿瘤骨病》 CAS 2007年第1期40-43,共4页 Chinse Journal Of Bone Tumor And Bone Disease
关键词 代谢性骨病 抗肿瘤作用 双膦酸盐 骨质疏松症 变形性骨炎 骨吸收功能 高钙血症 恶性肿瘤
分类号 R738 [医药卫生—肿瘤]
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参考文献32

  • 1[1]Rogers MJ.New insights into the molecular mechanisms of action of bisphosphonates.Curr Pharm Des,2003,9:2643-2658.
  • 2[2]Coxon FP,Rogers MJ.The role of prenylated small GTPbinding proteins in the regulation of osteoclast function.Calcif Tissue Int,2003,72:80-84.
  • 3[3]Monkkonen H,Auriola S,Lehenkari P,et al.A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogencontaining bisphosphonates.Br J Pharmacol,2006,147:437-445.
  • 4[4]Valentil MT,Bertoldol F,Dalle Carbonate L,et al.The effect of bisphosphonates on gene expression:GAPDH as a housekeeping or a new target gene? BMC Cancer,2006,6:49-55.
  • 5[5]Dalle Carbonare L,Valenti MT,Azzarello G,et al.Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells.Mol Cell Endocrinol,2005,240:23-31.
  • 6[6]Woodward JK,Neville-Webbe HL,Coleman RE,et al.Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro.Anticancer Drugs,2005,16:845-854.
  • 7[7]Dumon JC,Journe F,Kheddoumi N,et al.Cytostatic and apoptotic effects of bisphosphonates on prostate cancer cells.Eur Urol,2004,45:521-529.
  • 8[8]Gouin F,Ory B,Redini F,et al.Zoledronic acid slows down rat primary chondrosarcoma development,recurrent tumor progression after intralesional curretage and increases overall survival.Int J Cancer,2006,119:980-984.
  • 9[9]Evdokiou A,Labrinidis A,Bouralexis S,et al.Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis.Bone,2003,33:216-228.
  • 10[10]Kubista B,Trieb K,Sevelda F,et al.Anticancer effects of zoledronic acid against human osteosarcoma cells.J Orthop Res,2006,24:1145-1152.

同被引文献37

  • 1Liberman UA,Weiss SR,Broil J, et al.Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis[J].New Engl J Med,1995,333(22):1437-1444.
  • 2Black DM,Delmas PD,Eastell R,et al.Once-yearly zoledronic acid for treatment of postmenopausal osteopo- rosis[J].N Engl J Med,2007,356(18):1809-1822.
  • 3Reid IR,Miller P,Lyles Kyet al.Comparison of a single infusion of zoledronic acid with risedronate for Paget,s disease[J].New Engl J Med,2005,353(9);898-908.
  • 4Walsh J,Ward L,Stewart G,et al.A randomized clini- cal trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget's disease of bone[J].Bone,2004,34(4):747-754.
  • 5Senaratne SG,Colston KW.Direct effects of bisphospho- nates on breast cancer cells[J].Breast Cancer Res,2002,4(1):18-23.
  • 6Gnant M,Dubsky P,Fitzal F,et al.Maintaining bone density in patients undergoing treatment for breast canc- er:is there an adjuvant benefit?[J].Clin Breast Canc- er,2009,9(suppl I):S18-S27.
  • 7Winter M,Holen I,Coleman R.Exploring the anti- tumour activity of bisphosphonates in early breast canc- er[J].Cancer treatment reviews,2008,34(5):453-475.
  • 8Mauri D,Yalachis A,Polyzos NP,ei al.Does adjuvant bisphosphonate in early breast cancer modify the natural course of the disease? A meta-analysis of randomized controlled trials[J].J Nati Comp Canc Netw,2010,8(3):279-286.
  • 9Mhaskar R,Redzepovic J,Wheatley K,et al.Bisphos- phonates in multiple myeloma:a network meta-analy- sis[J].Cochrane Database Syst Rev,2012(5):cd003188.
  • 10Musto P,Petrucci MT,Bringhen S,et al.A multicenter,randomized clinical trial comparing zoledronic acid ver- sus observation in patients with asymptomatic myeloma[J].Cancer,2008,113(7):1588-1595.

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中国骨肿瘤骨病
2007年 第1期

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