摘要
目的研究结直肠癌组织微血管密度，探讨微血管密度与结直肠癌的关系，为开展抗结直肠癌血管形成治疗提供理论基础。方法62例结直肠癌标本造影后，用立体显微镜对结直肠癌中心组织，远、近端癌组织内，癌组织远、近端肠黏膜进行微血管密度计数，观测血管密度变化。结果结直肠癌远、近端癌组织内微血管密度与癌中心和癌远、近端正常肠黏膜相比差异有统计学意义。不同分化程度的结直肠癌比较差异无统计学意义。结论结直肠癌的发生、发展依赖于血管形成；微血管密度检测可用于指导临床治疗，提高治疗效果和患者的生存率；微血管密度与结直肠癌的恶性程度有待探讨。
Objective To measure microvessel density of colorectal carcinoma and investigate relationship between microvessel density and colorectal carcinoma so as to provide theoretical basis for anti-angiogenesis therapy. Methods The specimens surgically removed from 62 cases with colorectal carcinoma were perfused with radiography mixture. Then, the stereo microscopy was used to observe changes of microvessel density by measuring microvessel density at proximal, distal and central parts of the carcinoma as weU as at the proximal and distal paratumor mucosa. Results There was significant statistical difference upon microvessel density at proximal and distal parts of the carcinoma, compared with that at central part of carcinoma and that at proximal and distal para-tumor mucosa. Colorectal carcinoma with various differentiation showed no statistical difference. Conclusions Development of colorectal carcinoma is dependent on angiogenesis. The detection of microvessel density is helpful for guiding clinical therapy against colorectal carcinoma and can improve curative effect and survival rate of cases with colorectal carcinoma, Further study is needed to ascertain the relationship of microvessel density with malignancy degree of colorectal carcinoma.
出处
《中华消化外科杂志》
CAS
CSCD
2007年第2期129-131,共3页
Chinese Journal of Digestive Surgery
关键词
微血管密度
结肠癌
直肠癌
Microvessel density
Colon carcinoma
Rectal carcinoma
