摘要
收集浙医一院肿瘤科切除的肝癌病人31例，经病理证实均为肝细胞癌，83.87％伴结节性肝硬变。对照组17例。用ELISA法检测血清乙肝三系和HCV－Ab，用Nested－PCR法检测肝组织HBV-DNA和HCV-RNA。本研究得到以下结论：1）血清中抗HCV检测不能完全反映肝内是否曾有HCV感染情况。2）肝癌组织中确实存在HCV－RNA。3）肝细胞癌中，绝大多数存在乙型肝炎病毒感染的背景，血清、肝组织检测乙肝病毒标志均能反映其感染状态。4）肝癌中存在着HBV、HCV重叠感染的情况。
The relationship between HBy,HCV infection and primary liver cancer was studied in 31 patients with hepatocellular carcinoma proven pathologi cally.In 83.87% of this series nodular cirrhosis of liver was present.Hepatitis B markers and HCV-Ab in the serum of patients have been tested with ELISA method.HBV-DNA and HCV-RNA in the liver tissue have been examined with Nested PCR method.Based on findings of this study the following conclusions have been drawn:1)Anti-HCV test does not necessarily reflect presence or grade of HCV infection.2)HCV-RNA does exist in liver tissue of liver cancer.3)Most patients with hepatocellular carcinoma have infectious background of hepatitis B virus as manifested by presence of hepatitis B marker in serum and liver tissue as well.4)Overlapping infection of HBV and HCV exists in liver cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第2期108-111,共4页
Chinese Journal of Clinical Oncology
