摘要
目的:研究玻璃体腔内单次注射曲安奈德(TA)治疗非增殖性弥漫性糖尿病黄斑水肿(DME)的疗效及安全性。方法:玻璃体腔内单次注射TA4mg/0.1mL治疗非增殖性弥漫性DME25眼,观察治疗前后视力、黄斑区视网膜神经感觉层厚度、眼压的变化以及并发症的发生情况。结果:治疗后1mo与治疗前相比,视力提高显著(P=0.0004);治疗后3mo与治疗后1mo比较,视力显著提高(P=0.0006);治疗后6mo与治疗前相比,视力无显著性差异(P=0.0935)。治疗后1mo黄斑区周围1.00mm范围内视网膜神经感觉层厚度与治疗前相比,显著降低(P=0.0000);治疗后3mo与治疗后1mo相比,显著降低(P=0.0303);治疗后6mo后与治疗后3mo相比,显著升高(P=0.0000),但与治疗后1mo相比,仍显著降低(P=0.0000)。治疗后10,40min眼压与治疗前相比显著升高(P=0.0000);而治疗后1d与治疗前相比无显著性差异(P=0.1766)。结论:玻璃体腔内单次注射TA4mg/0.1mL治疗非增殖性弥漫性DME,短期疗效确实,可以明显减轻水肿、改善患者视功能,安全性较高。
AIM： To observe clinical therapeutic effects and safety of single intracavity injection of triamcinolone acetonide （TA） for nonproliferative diffuse diabetic macular edema（DME）.
METHODS： Twenty-five eyes with nonproliferative diffuse DME received single injection of 4mg/0.1mL TA into vitreous. Mean best-corrected visual acuity, thickness of the neurosensory retina, intraocular pressure （IOP） and adverse reaction were observed and analyzed.
RESULTS： Mean best-corrected visual acuity （BCVA） at one month follow-up was significantly better than that at baseline （P =0.0004）. After three months follow-up, BCVA improved significantly compared to that after one month follow-up （P=-0.0006）. The six months follow-up BCVA had no significantly difference with the baseline （P= 0.0935）. The thickness of neurosensory retina at 1.00mm from the macular fovea at one month after injection had an significantly decline compared to baseline （P =0.0000）, and it at three months follow-up time points was significantly fewer compared to that at one month follow-up time points （P=0.303）. However, at six months follow-up the thickness of neurosensory retina increased again, but it was still fewer than the baseline （P =0.0000）. Mean IOP at ten minutes and forty minutes follow-up were significantly higher （P=0.0000） than the baseline, while it decreased to the normal level one day later.
CONCLUSION： Single intracavity injection of 4mg/0.1mL TA for nonproliferative diffuse DME is an effective and safe method.
出处
《国际眼科杂志》
CAS
2007年第2期444-446,共3页
International Eye Science
