摘要
【目的】探讨糖尿病应激期禁食患者胰岛素泵的应用。【方法】121例禁食糖尿病患者中,根据胰岛素的应用方法不同分为:泵组37例,应用优泌乐(Humalog)。来得时皮下注射组41例,应用甘精胰岛素(Insul-inglargine)。NPH皮下注射组43例,应用诺和灵N(Novolin N)。【结果】泵组、来得时组与NPH组在相同治疗目标下,达标所应用时间泵组:(3.72±1.41)d、来得时组:(6.4±1.77)d、NPH组:(8.6±3.1)d、(P<0.05)。胰岛素用量泵组:(39.10±3.16)IU/d、来得时组:(42±4.27)IU/d、NPH组:(53±4.00)IU/d、胰岛素用量比较(P<0.05)。空腹血糖泵组;(7.3±2.53)mmol/L、来得时组:(9.5±4.51)mmol/L、NPH组:(10.1±3.84)mmol/L、空腹血糖泵组与来得时组、泵组与NPH组比较(P<0.05),来得时与NPH组比较(P=0.513)。低血糖的发生率;泵组:5.4%,来得时组:7.32%、NPH组:9.3%,3组比较(P>0.05)。【结论】胰岛素泵强化治疗组比来得时皮下注射组、NPH皮下注组,治疗所需时间更短,胰岛素用量少,血糖控制更理想,低血糖的发生率无明显增加,且剂量调节更加方便,是一种非常有效且安全的方法,值得推广。特别适合需禁食的糖尿病患者。
[Objective] To discuss the application of insulin pump in the treatment of diabetic patients in the fasting peried. [Methods] A total of 121 diabetic paftients in fasting period were divided into three groups: (1) Pump group: 37 patients were treated with pumping Humalong. (2) Glargine subcutaneous injection group: 41 patients were treated with glargein. (3) NPH subcutaneous injection group: 43 patients were treated with Novolin-N. [Results] The time of approaching the standard level in three groups were as follows: pump group: (3.72± 1.41) d, glargine group: (6.4± 1.77) d, NPHgroup: (8.6±3.1)d (P〈0.05). Insulin dosage: pump group: (39.10±3.161) IU/d, glargine group: (42±4.27) IU/d, NPH group: (53±4.00) IU/d (P〈0.05). Fasting blood glucose: pump group: (7.3 ±2.53) mmol/L, glarginegroup: (9.5±4.51) mmol/L (P〈0.05), NPHgroup: (10.1±3.84) mmuI/L. Pump group vs glargine group (P 〈 0.05), pump group vs NPH group (P 〈 0.05), glargine group vs NPH group (p = 0.513). Prevalence of hypoglycemia: pump group: 5.4%, glargine group: 7.32%, NPH group: 9.3% (P 〉 0.05). [Conclusion] In the treatment of diabetic in fasting period, the pump method providies a better glycemic control without increasing the rate of hypoglycemia and convenient doses adjustment and is an efficient and safety method.
出处
《武警医学院学报》
CAS
2007年第3期294-296,共3页
Acta Academiae Medicinae CPAPF
关键词
禁食
胰岛素泵
低血糖
Fasting
insulin pump
Hypoglycemia