摘要
目的:探讨中药杏香兔耳风治疗宫颈炎的作用机理。方法:建立大鼠宫颈炎动物模型,分别于给药4天、10天后观察杏香兔耳风不同剂量组对大鼠宫颈粘膜表皮生长因子(EGF)表达的影响,并进行病理组织学检查。结果杏香兔耳风高、中剂量组对苯酚胶浆造成的实验性大鼠宫颈炎模型,给药4天后,可明显升高宫颈粘膜EGF表达,与模型对照组比较具有显著性差异(其中高剂量组P<0.01,中剂量组P<0.05);给药10天后,各组宫颈粘膜EGF表达无明显差异;病理组织学检查结果也表明,杏香兔耳风高、中剂量组对大鼠宫颈炎有一定的治疗作用,以高剂量组最为明显。结论:杏香兔耳风对大鼠宫颈炎治疗作用与其促进大鼠宫颈粘膜EGF的早期表达有一定关系。
Objective： to study the mechanism of Ainsliaea fragrans Champ treated cervicitis. Method： Establish the model of cervicitis by hydroxybenzene mucilage in rats. After 4 and 10 days,observe the effect of Ainsliaea fragrans Champ on EGF expressed of cervix mucosae of rats of different dose group,and analyzed its pathomorphology. Results： Comparing with model group, Ainsliaea fragrans Champ high dose group and middle dose group can significantly heighten the EGF levels of rat cervix mucosae after 4 days. after 10 days, the EGF levels of all groups have no significant difference, on the other hand, by histopathologic examination we can find Ainsliaea fragrans Champ high dose group and middle dose group could improve rat cervicitis, and high dose group has more significant therapeutic effect, Conclusion： Ainsliaea fragrans Champ＇s therapeutic effect has a relation with its raising EGF express of earlier period in rat cervtx mucosae.
出处
《江西中医学院学报》
2007年第2期72-73,共2页
Journal of Jiangxi College of Traditional Chinese Medicine
关键词
杏香兔耳风
宫颈炎
EGF
Ainsliaea fragrans Champ
cervicitis
EGF
