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果蝇抗微生物肽基因的免疫诱导模式 被引量：3

Induction pattern of antimicrobial peptides genes in Drosophila
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摘要 果蝇作为一种模式昆虫,为研究昆虫和人类的先天免疫发挥了重要作用。目前对果蝇体内免疫诱导产生的抗微生物肽多基因家族在分子进化、抗菌功能的分子特征和免疫诱导表达的信号传递机制等方面的研究进展,进一步加深了人们对昆虫乃至其他动物和人类先天免疫模式的认识,为研究其他昆虫特别是作为主要农林害虫的鳞翅目昆虫的先天免疫机制发挥了重要作用。本文集中对黑腹果蝇Drosophila melanogaster抗微生物肽及其免疫模式的研究结果和最新进展进行了介绍,其中包括作者近几年的研究结果。 Drosophila melanogaster is an attractive model insect for dissecting the innate immunity system of invertebrates and vertebrates. The fruitful results on several aspects of antimicrobial peptides （AMPs）, such as cloning and characterization of AMP genes, the signal transduction path way and the evolution of the AMPs muhi-gene families in Drosophila species, have contributed a lot to the deep understanding of the innate immunity mechanism of insects and other organisms. Such results may also shed further light on the mechanism of immunity of some agricultural lepidopteran pest insects and the strategies of pest control. In this review, we summarized the structures, biological properties, the induction pattern, the signal transduction pathway, as well as the evolution of AMPs and their multi-gene families.
作者 邓小娟 杨婉莹 李怡峰 王文献 温硕洋 夏庆友 曹阳
机构地区 华南农业大学动物科学学院蚕丝科学系 华南农业大学资源环境学院昆虫学系 西南大学蚕学与生物技术学院农业部蚕桑学重点实验室
出处 《昆虫学报》 CAS CSCD 北大核心 2007年第4期405-415,共11页 Acta Entomologica Sinica
基金 国家重点基础研究发展计划"973"项目(2005CB121000) 国家自然科学基金项目(30370716) 广东省自然科学基金项目(010294 032256 04020553) 广东省科学技术计划重点项目(2003C104042)
关键词 果蝇 抗微生物肽 多基因家族 免疫 Drosophila antimicrobial peptides muhi-gene family immunity
分类号 Q966 [生物学—昆虫学]
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参考文献68

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共引文献26

同被引文献82

  • 1周绪霞,陆平,李卫芬.昆虫防御素及其研究进展[J].免疫学杂志,2004,20(z1):121-123. 被引量：8
  • 2李晨华,李彦,谢静霞,唐立松.荒漠-绿洲土壤微生物群落组成与其活性对比[J].生态学报,2007,27(8):3391-3399. 被引量：22
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引证文献3

二级引证文献5

昆虫学报
2007年 第4期

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