摘要
基因治疗已被视为人类最有希望彻底征服遗传性疾病和肿瘤等重大疾病的手段之一,发展非病毒基因转运系统对基因治疗的临床应用具有十分重要的推进作用。目前已发展了缓释系统介导的DNA体内转移,物理方法介导的基因转移及基于流体力学的基因转运系统。
Although viral vector systems are efficient to transfect genes into a variety of tissues, safety issues remain in relation to human gene therapy. This review describes the basic principles behind various physical and chemical methods for gene transfer and assesses the advantages and performance of such approaches, compared to other transfection systems. In particular, the efficiency of gene delivery, the toxicity, in vivo feasibility, and targeting ability of different non-viral methodologies are discussed and evaluated.
出处
《国际病理科学与临床杂志》
CAS
2007年第2期141-144,共4页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金(30400256)~~
