摘要
运用同步辐射X射线荧光(Synchrotron radiation X-ray fluorescence,SRXRF)技术分析鹿茸血处理前后的去势大鼠股骨元素含量及与骨密度(Bone mineral density,BMD)的关系。分别取出假手术组、去势组和去势后经鹿茸血处理组的雌性Wistar大鼠的左股骨,经SRXRF分析,结果显示:元素Ca、P、Zn和Sr之间有非常好的正相关性。与假手术组相比,去势大鼠股骨元素Ca、P、Zn和Sr的相对强度均有降低,其中元素Ca、P的相对强度明显降低(p<0.05),其BMD也显著降低(p<0.05),说明由于Ca和P元素的大量丢失,导致骨质疏松。用鹿茸血处理后,去势大鼠股骨元素Ca、P、Zn的相对强度都有不同程度的升高,因而其BMD也显著升高(p<0.05),骨质疏松得到显著恢复。结果表明:鹿茸血有助于维持骨组织中微量元素Zn的含量,进而保持骨Ca和P的含量,从而提高BMD,减少骨质疏松的发生。
To investigate the relationship between bone element contents and bone mineral density （BMD）, left femur of sham-operated rats （SHAM, n=5）, ovariectomized rats （OVX, n=5） and antler hemo-treated ovariectomized rats （OVX＋ antler hemo, n=5） were analyzed by synchrotron radiation X-ray fluorescence （SRXRF） microprobe. The results showed that there were very good positive correlations among contents of Ca, P, Zn and Sr. In comparison to the SHAM group, decreased relative intensities of Ca, P, Zn and Sr （especially Ca and P, p〈0.05） were observed in femur of the OVX group, which showed significant decrease （p〈0.05） of the BMD. The results indicate that loss of Ca and P in bone will cause osteoporosis. On the other hand, increased relative intensities of Ca, P and Zn in femur, and the BMD （p〈0.05）, of the anlter hemo-treated OVX group were found, in comparison to the OVX group. This suggests that anlter hemo may help cure osteoporosis through maintaining bone contents of Zn, Ca and P, and increasing the BMD.
出处
《核技术》
CAS
CSCD
北大核心
2007年第5期407-410,共4页
Nuclear Techniques
基金
中国科学院研究生院院长基金资助(编号:Y1016)项目
关键词
元素分析
骨质疏松
股骨
骨密度
同步辐射X射线荧光
Element analysis, Osteoporosis, Femur, Bone mineral density, Synchrotron radiation X-ray fluorescence
