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羟乙基淀粉扩容液临床研究进展 被引量：23

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摘要 目的有效循环血容量是维持机体正常代谢和生命活动的基本保证。现代液体治疗观念认为,纠正低血容量状态应首选晶体液及血浆代用品进行容量替代治疗。作为血浆代用品中的典型代表,羟乙基淀粉在扩容治疗中的作用越来越为人们所关注。笔者主要介绍近年来羟乙基淀粉的相关研究进展,为临床合理应用提供参考。方法对近年来有代表性的相关文献进行分析和总结。结果目前低取代级中分子羟乙基淀粉——HES200/0.5已经在临床扩容治疗中得到广泛应用。在此基础上,第三代羟乙基淀粉产品——HES130/0.4在理化特性、扩容效果及安全性等方面又有新的改进,使其具有更为广阔的应用前景。结论羟乙基淀粉溶液在扩容治疗中占有重要地位。与血浆及白蛋白等胶体扩容液相比,HES200/0.5尤其是HES130/0.4不仅具有良好的扩容效果及较少的不良反应,而且对节约用血、缓解血源紧张及减少输血并发症也具有重要的意义,将成为现代扩容治疗更为理想的选择。
作者 周欣 张晓乐
机构地区 北京大学第三医院药剂科
出处 《中国药学杂志》 CAS CSCD 北大核心 2007年第9期646-649,共4页 Chinese Pharmaceutical Journal
关键词 血容量扩充剂 羟乙基淀粉 扩容治疗 HES200/0.5 HES130/0.4
分类号 R654 [医药卫生—外科学]
  • 相关文献

参考文献26

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二级参考文献16

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共引文献20

同被引文献172

引证文献23

二级引证文献80

中国药学杂志
2007年 第9期

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