摘要
目的对非小细胞肺癌患者放疗前行99Tcm-HL91显像,与放疗疗效进行比较,探讨99Tcm-HL91显像在预测放疗敏感性方面的应用价值。方法对35例经CT引导下穿刺或支气管镜检查病理确诊的非小细胞肺癌患者,放疗前一周内静脉注射99Tcm-HL91740MBq(20mCi),4h后进行99Tcm-HL91平面及断层显像。半定量分析:利用感兴趣区(ROI)技术,勾画圆形感兴趣区,计算肿瘤与对侧正常肺组织(T/N)的放射性比值。随访患者放疗疗效,完全缓解(CR)和部分缓解(PR)为治疗有效组,无变化(NC)和增大(PD)为无效组。结果99Tcm-HL91平面显像:35例非小细胞肺癌患者中的30例显像阳性;断层显像:33例显像阳性。半定量分析:断层像4h的T/N比值显著高于平面像的T/N比值。放疗后完全缓解(CR)5例,部分缓解(PR)14例,无变化(NC)7例,增大(PD)4例,死亡或失访共5例,放疗有效组(CR+PR)与放疗无效组(NC+PD)断层显像的T/N比值分别为1.747±0.301,2.087±0.478,差异具有显著性(t=2.363,P=0.026)。结论放疗前99Tcm-HL91肺显像可预测非小细胞肺癌的放疗敏感性。
Objective Patients with non-small cell lung cancer （NSCLC） were performed ^99Tc^m-HL91 imaging pre-treatment. The purpose is to evaluate the value of ^99Tc^m-HL91 imaging in predicting the radio-therapeutic effect of the NSCLC. Methods Thirty-five patients with untreated NSCLC were performed SPECT and planar imaging at 4 hour after injection of ^99Tc^m-HL91 within one week before radiotherapy. ROIs were drawn in imaging of tumor and symmetry in lung planar scan, and the radioactivity ratios of tumor-to-normal tissue were calculated. The patients＇ therapeutic effects of radiotherapy were observed. Effective radiotherapy （CR＋PR） and ineffective radiotherapy （NC＋PD） were discriminated by CT scan. Results ^99Tc^m-HL91 imaging： visible uptake was showed was showed visible uptake in 30 out of 35 NSCLC patients. SPECT imaging： 33 out of 35 were positive. Semiquantitative analysis： tumor-to-normal tissue ratios （T/N）, significance was found between planar imaging and SPECT. There were CR 5 cases, PR 14 cases, NC 7 cases, PD 4 cases, death and failure of follow-up survey 5 cases. The groups of effective radiotherapy （CR＋PR） and ineffective radiotherapy （NC＋PD）, which T/N average value were 1.747 ±0.301, 2. 087±0. 478 respectively, had significant difference （t = 2.363, P = 0.026）. Conclusion ^99Tc^m-HL91 hypoxic imaging of pre-radiotherapy can predict the radiosensitivity of NSCLC.
出处
《中国医学影像技术》
CSCD
北大核心
2007年第4期599-601,共3页
Chinese Journal of Medical Imaging Technology
