期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IGF-Ⅱ在足月妊娠胎盘中的表达及与胎儿出生体重关系的探讨 被引量：1

Evaluation of expression of IGF-Ⅱ in term placenta and its relationship with birth weight
下载PDF
导出
摘要 目的研究胰岛素样生长因子-Ⅱ(insulin-like growth factor-Ⅱ,IGF-Ⅱ)在足月胎盘中的表达及与胎儿出生体重的相关性。方法采用逆转录-聚合酶链式反应(RT-PCR)技术对足月分娩的巨大儿与正常体重新生儿胎盘组织中IGF-Ⅱ mRNA的表达水平进行检测并对比其差异性。结果①IGF-Ⅱ在巨大儿组及对照组中均有表达,巨大儿组中IGF-Ⅱ mRNA表达水平为(1.19±0.31),表达率为93.8%,对照组中表达水平(1.15±0.28),表达率为88.9%,两组间表达水平及表达率差异均无显著统计学意义(P>0.05);②胎盘组织中IGF-Ⅱ mRNA的表达丰度与新生儿出生体重无明显相关性(r=-0.216,P=0.213)。结论IGF-Ⅱ mRNA在足月妊娠胎盘组织中有表达,其表达量与新生儿出生体重无明显相关性,IGF-Ⅱ可能不是妊娠晚期胎盘中影响胎儿生长的主要因子。 Objective To investigate the expression of IGF - Ⅱ in term placenta and its relationship with birth weight. Methods IGF- Ⅱ mRNA was measured by RT - PCR. Difference was compared between macrosomia and normal birth weight neonate. Results （1） IGF-Ⅱ mRNA was expressed in placenta at term. The rate and level of its expression was 93.8%, （1.19±0.31） in macrosomias and 88.9%, （1.15±0.28） in normal birth weight neonates, respectively. No significant difference was found between the two groups （P〉0.05）. （2） No obvious correlation was found between expression of IGF-Ⅱ in term placenta and the birth weight （r=-0. 216, P= 0. 213）. Conclusions IGF - Ⅱ mRNA is expressed in term placenta. IGF- Ⅱ may not be the main factor affecting the fetal development.
作者 梁梅英 陈梦捷 孙蓬明 魏丽惠
机构地区 北京大学人民医院妇产科
出处 《中国妇产科临床杂志》 2007年第3期210-212,共3页 Chinese Journal of Clinical Obstetrics and Gynecology
关键词 胰岛素样生长因子-Ⅱ 巨大儿 逆转录-聚合酶链式反应 IGF - Ⅱ maerosomia RT - PCR
分类号 R714.1 [医药卫生—妇产科学]
  • 相关文献

参考文献7

  • 1[1]Freese L.G,Rehfeldt C,Fuerbass R.Exogenous somatotropin alters IGF axis in porcine endometrium and placenta.Domestic Animal Endocrinology,2005,29:457-475.
  • 2李真,林桂兰,王智,成娅.妊高征胎盘滋养细胞浸润能力的检测及胰岛素样生长因子-II、转化生长因子-β1对其的影响[J].生殖医学杂志,2004,13(4):198-201. 被引量：8
  • 3[3]Thomsen BM,Clausen HV,Larsen LG.Patterns in expression of insulin-like growth factor-Ⅱand of proliferative activity in the normal human first and third trimester placenta demonstrated by non-isotopic in situ hybridization and immunohistochemical staining for MIB-1.Placenta,1997,18:145-154.
  • 4[4]Millar LK,Reiny R,Yamamoto SY,et al.Relaxin causes proliferation of human amniotic epithelium by stimulation of insulin-like growth factor-Ⅱ.Am J Obstet Gynecol,2003,188:234-241.
  • 5[5]Roth S,Abernathy MP,Lee Wei-Hua,et al.Insulin-like growth factors Ⅰand Ⅱ peptide and messenger RNA levels in macrosomic infants of diabetic pregnancies.J Soc Gyneclo Invest,1996,3:78-84.
  • 6[6]Constancia M,Hemberger M,Hughes J,et al.Placental -specific IGF-Ⅱ is a major modulator of placental and fetal growth.Nature,2002,417:945-948.
  • 7[7]Street ME,Seghini P,Ziveri MA.Interleukin-6 and insulin-like growth factor system relationships and differences in the human placenta and fetus from the 35th week of gestation.Growth Hormone & Igf Research,2006,16:365-372.

二级参考文献11

  • 1Thomsen BM,Clausen HV,Larsen LG,et al. Patterns in expression of insulin-like growth factor-II and of proliferative activity in the normal human first and third trimester placenta demonstrated by non-isotopic in situ hybridization and immunohistochemical
  • 2Irwin JC,Suen LF,Faessen GH,et al. Insulin-like growth factor(IGF)-II inhibition of endometrial stromal cell tissue inhibitor of metalloproteinase-3 and IGF-binding protein-1 suggests paracrine interactions at the decidua:trophoblast interface during huma
  • 3Liu KH,Zhou Y,Janatpour M,et al. Human cytotrophoblast differentiation/invasion is abnormal in preeclampsia[J]. Am J Pathol,1997,151(6):1809-1818.
  • 4Chakraborty C,Gleeson LM,McKinnon T,et al. Regulation of human trophoblast migration and invasiveness[J] . Can J Physiol Pharmacol,2002,80(2):116-124.
  • 5Fisher SJ,Damsky CH. Human cytotrophoblast invasion[J]. Semin Cell Biol,1993, 4(1):183-188.
  • 6Liu HC,He ZY,Mele CA,et al. Expression of IGFs and their receptors is a potential marker for embryo quality[J]. Am J Reprod Immunol,1997,38(2):237-245.
  • 7Selick CE, Horowitz GM, Gratch M, et al. Immunohistochemical localization of transforming growth factor-beta in human implantation sites[J]. J Clin Endocrinol Metab,1994,78(3): 592-596.
  • 8Lysiak JJ, Hunt J, Pringle GA, et al. Localization of transforming growth factor beta and its natural inhibitor decorin in the human placenta and decidua throughout gestation[J]. Placenta,1995, 16(3): 221-231.
  • 9Dennler S, Goumans MJ, Peter TD. Transforming growth factor beta signal transduction[J]. J Leukoc Biol,2002,71(5): 731-740.
  • 10乐杰.妇产科学（第5版）[M].北京:人民卫生出版社,2001.139.

共引文献7

同被引文献13

  • 1周建军,胡娅莉.IGF系统对巨大儿形成的作用机制研究进展[J].国外医学（妇幼保健分册）,2005,16(5):279-282. 被引量：4
  • 2姚金翠,胡娅莉,王志群,戴毅敏,凌静娴,叶晓东.胰岛素样生长因子2基因印迹状态及其启动子活性在巨大儿胎盘组织中的变化[J].中华妇产科杂志,2007,42(5):309-314. 被引量：2
  • 3Zhang X, Decker A, Platt RW, et al. How big is too big?The perinatal consequences of fetal macrosomia. Am J Obstet Gynecol, 2008, 198: 517. e1-517, e6.
  • 4Sferruzzi - Perri AN, Owens JA, Pringle KG, et al. The neglected role of insulin- like growth factors in the maternal circulation regulating fetal growth. Physio, 2011, 589: 7-20.
  • 5Lindsay RS, Westgate JA, Beattie J, et al. Inverse changes in fetal insulin- like growth factor (IGF) - 1 and IGF binding protein- 1 in association with higher birth weight in maternal diabetes. Clin Endoerinol (Oxf), 2007, 66:P322 - 328.
  • 6Esad K, Selim K, Mustafa A, et al. Serum insulin- like growth factor- I (IGF- I) IGF binding protein - a (IGFBP- 3) and leptin levels are related to abdominal aorticintimamedia thickness in macrosomic newborns. Growth Hormone IGFResearch, 2007, 17: 26-32.
  • 7Wiznitzer A, Reece EA, Homko C, et al. Insulin- like growth factors, their binding proteins, and fetal macrosomia in offspring of nondiabetic pregnant women. Am J Perinatol, 1998, 15: 23-28.
  • 8Forbes K, Souquet B, Garside R, et al. Transforming growth factor- {beta} (TGF {beta}) receptors Ⅰ/Ⅱ differentially regulate TGF {beta} 1 and IGF - binding protein - 3 mitogenie effects in the human placenta. Endocrinology, 2010, 151: 1723-1731.
  • 9Randhawa RS. The insulin like growth factor system and fetal growth restrictionn. Pediatr Endocrinol Rev, 2008, 6: 235 - 240.
  • 10Hua Jiang, Pengcheng Xun, Guanghua Luo, et al. Levels of insulin- like growth factors and their receptors in placenta in relation to maerosomia. Asia Pac J Clin Nutr, 2009, 18: 171 - 178.

引证文献1

二级引证文献9

中国妇产科临床杂志
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部