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T细胞受体基因转导的研究和应用 被引量：5

The application and research of TCR gene transduction
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摘要 T细胞受体（TCR）作为T细胞识别抗原的分子，在免疫应答和免疫调节中发挥重要的作用。利用转基因技术，将识别特定抗原的TCR基因转导到正常T细胞中，使其强制性表达了识别特异抗原TCR，从而达到发挥特异性免疫效应的目的，为产生有效的特异性免疫治疗开辟了一条新途径。 As the molecule of recognizing the specific antigen of T lymphocyte, T cell receptor （TCR） plays an important role in the immunity response and immunity regulation. Utilizing the technology of gene transfer, the specific TCR gene was transferred into the normal T lymphocyte. T lymphocyte was forced to express the specific TCR, and then can exercise the specific immunological effect. It provides a new strategy to the specific immunotherapy.
作者 李闯 李扬秋（审校）
机构地区 暨南大学医学院血液病研究所硕士研究生 暨南大学医学院血液病研究所
出处 《国际免疫学杂志》 CAS 2007年第3期139-143,共5页 International Journal of Immunology
基金 广东省自然科学基金重点项目（05103293）
关键词 T细胞受体 免疫治疗 基因转导 TCR Immunotherapy Gene transduction
分类号 R4 [医药卫生—临床医学]
  • 相关文献

参考文献23

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二级参考文献5

共引文献13

同被引文献55

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  • 2岑东芝,李扬秋,陈少华,杨力建,郁志.APL患者外周血TCR Vα亚家族T细胞分布和增殖特点[J].临床肿瘤学杂志,2007,12(2):81-84. 被引量：7
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引证文献5

二级引证文献11

国际免疫学杂志
2007年 第3期

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